Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Royal College of Medicine Perak, Universiti Kuala Lumpur, Ipoh, Perak, 30450, Malaysia.
School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor, 47500, Malaysia.
Drug Des Devel Ther. 2023 Apr 8;17:1065-1078. doi: 10.2147/DDDT.S388490. eCollection 2023.
Streptonigrin is an aminoquinone alkaloid isolated from and is gaining attention as a drug molecule owing to its potential antitumor and antibiotic effects. It was previously used as an anticancer drug but has been discontinued because of its toxic effects. However, according to the most recent studies, the toxicity of streptonigrin and its structurally modified derivatives has been reduced while maintaining their potential pharmacological action at lower concentrations. To date, many investigations have been conducted on this molecule and its derivatives to determine the most effective molecule with low toxicity to enable new drug discovery. Therefore, the main objective of this study is to provide a comprehensive review and to discuss the prospects for streptonigrin and its derived compounds, which may boost the molecule as a highly interesting target molecule for new drug design, development and therapy. To complete this review, relevant literature was collected from several scientific databases, including Google Scholar, PubMed, Scopus and ScienceDirect. Following a complete screening, the obtained information is summarized in the present review to provide a good reference and accelerate the development and utilization of streptonigrin and its derivatives as pharmaceuticals.
棘霉素是一种从 中分离得到的氨基醌生物碱，由于其潜在的抗肿瘤和抗生素作用，作为一种药物分子引起了人们的关注。它以前曾被用作抗癌药物，但由于其毒性作用已被停用。然而，根据最近的研究，棘霉素及其结构修饰衍生物的毒性已经降低，同时在较低浓度下保持其潜在的药理作用。迄今为止，已经对该分子及其衍生物进行了许多研究，以确定具有低毒性的最有效分子，从而能够发现新药。因此，本研究的主要目的是提供全面的综述，并讨论棘霉素及其衍生化合物的前景，这可能会推动该分子成为新药设计、开发和治疗的极具吸引力的靶标分子。为了完成这项综述，从几个科学数据库（包括 Google Scholar、PubMed、Scopus 和 ScienceDirect）中收集了相关文献。经过全面筛选，现将获得的信息总结在本综述中，为加速棘霉素及其衍生物的开发和利用提供良好的参考。
