新冠肺炎患者的定量蛋白质组学分析：胎球蛋白-A和纤连蛋白作为先天免疫反应的潜在调节因子

Quantitative proteomics analysis of COVID-19 patients: Fetuin-A and tetranectin as potential modulators of innate immune responses.

作者信息

Alghanem Bandar, Mansour Fatmah A, Shaibah Hayat, Almuhalhil Khawlah, Almourfi Feras, Alamri Hassan S, Alajmi Hala, Rashid Mamoon, Alroqi Fayhan, Jalouli Maroua, Harrath Abdel Halim, Boudjellal Mohammad, Barhoumi Tlili

机构信息

Medical Research Core Facility and Platforms, King Abdullah International Medical Research Centre, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

出版信息

Heliyon. 2023 Apr;9(4):e15224. doi: 10.1016/j.heliyon.2023.e15224. Epub 2023 Apr 9.

Treatment of severe cases of coronavirus disease 2019 (COVID-19) is extremely important to minimize death and end-organ damage. Here we performed a proteomic analysis of plasma samples from mild, moderate and severe COVID-19 patients. Analysis revealed differentially expressed proteins and different therapeutic potential targets related to innate immune responses such as fetuin-A, tetranectin (TN) and paraoxonase-1 (PON1). Furthermore, protein changes in plasma showed dysregulation of complement and coagulation cascades in COVID-19 patients compared to healthy controls. In conclusion, our proteomics data suggested fetuin-A and TN as potential targets that might be used for diagnosis as well as signatures for a better understanding of the pathogenesis of COVID-19 disease.