Kavcar Zubeyr, Civan Hasret Ayyildiz, Taskin Didem Gulcu, Hatipoglu Sadik Sami
Department of Pediatrics, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Türkiye.
Department of Pediatric Gastroenterology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Türkiye.
Sisli Etfal Hastan Tip Bul. 2023 Mar 21;57(1):73-78. doi: 10.14744/SEMB.2022.32708. eCollection 2023.
We aimed to evaluate the frequency of extraintestinal manifestations (EIM) in children with inflammatory bowel disease (IBD) and the correlation of EIM with disease activity index, disease type and disease age.
Records of patients who were under the 18 years of age and followed up with the diagnosis of IBD were included in the study. The demographic characteristics of the patients, the age of the patients, the sex of the patients, the type of disease and the age of the disease were recorded. When patients were enrolled in the study disease activity indexes were calculated by examining the physical examination and laboratory values of the patients in their last visits, by using the Pediatric Ulcerative Colitis Activity Index (PUCAI) in Ulcerative Colitis (UC) and the Pediatric Crohn's Disease Activity Index (PCDAI) in Crohn's Disease (CD).
It was conducted with a total of 44 patients, 40.9% (n=18) females and 59.1% (n=26) males diagnosed with IBD. The ages of the patients participating in the study ranged from 8 to 19 and the mean was found to be 14.64±3.19 years. According to the type of disease; 27.3% of the patients were CD and 72.7% were UC. When the disease activity is examined; 37.2% were in remission, 37.2% were mild, 16.3% moderate and 9.3% severe. The incidence of EIM in females is 77.8% and 65.4% in males. The incidence of EIM is 75% in CD and 68.8% in UC. Hepatobiliary involvement was detected in 41.5% (n=17) of the patients, joint involvement in 29.5% (n=13), osteopenia in bone in 16.3% (n=7), osteoporosis in 7% (n=3), ocular involvement (uveitis) in 2.3% (n=1) and skin involvement (erythema nodosum) in 2.3% (n=1).
EIM are common in childhood IBD patients. It should be kept in mind that EIM are as common in UC as CD.
我们旨在评估炎症性肠病（IBD）患儿肠外表现（EIM）的发生率，以及EIM与疾病活动指数、疾病类型和发病年龄的相关性。
本研究纳入了年龄在18岁以下且经诊断为IBD并接受随访的患者记录。记录患者的人口统计学特征、年龄、性别、疾病类型和发病年龄。在患者纳入研究时，通过检查患者上次就诊时的体格检查和实验室值，使用溃疡性结肠炎（UC）的小儿溃疡性结肠炎活动指数（PUCAI）和克罗恩病（CD）的小儿克罗恩病活动指数（PCDAI）来计算疾病活动指数。
本研究共纳入44例诊断为IBD的患者，其中女性占40.9%（n = 18），男性占59.1%（n = 26）。参与研究的患者年龄在8至19岁之间，平均年龄为14.64±3.19岁。根据疾病类型；27.3%的患者为CD，72.7%为UC。检查疾病活动情况时；37.2%处于缓解期，37.2%为轻度，16.3%为中度，9.3%为重度。女性EIM的发生率为77.8%，男性为65.4%。CD中EIM的发生率为75%，UC中为68.8%。41.5%（n = 17）的患者检测到肝胆受累，29.5%（n = 13）有关节受累，16.3%（n = 7）有骨质减少，7%（n = 3）有骨质疏松，2.3%（n = 1）有眼部受累（葡萄膜炎），2.3%（n = 1）有皮肤受累（结节性红斑）。
EIM在儿童IBD患者中很常见。应牢记EIM在UC和CD中同样常见。
