Shuchismita Shuchismita, Jamal Iffat, Raman Ravi Bhushan, Choudhary Vijayanand
Department of Hematology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.
J Lab Physicians. 2022 Oct 20;15(1):84-89. doi: 10.1055/s-0042-1757233. eCollection 2023 Mar.
The actual incidence and demographic profile of hematological malignancies are unknown in Bihar because of lack of population-based cancer registry (PBCR) data and specialized tertiary cancer center facilities. The objective of this study was to estimate the prevalence, clinico-hematological profile and subtyping of acute leukemia cases by retrospective medical records. A retrospective study was conducted in the Department of Hematology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India, over 2 years from July 2019 to June 2021. A total of 176 cases with relevant clinical features and hematological findings were involved in the study. Medical records were studied and data were retrieved. Data were recorded and analyzed using SPSS version 25. A total of 176 cases with relevant clinical features and hematological findings were involved in the study. Acute myeloid leukemia (AML) was most prevalent (52.8%), followed by acute lymphoblastic leukemia (ALL) (34.1%) and unclassified acute leukemia cases (13.1%). Flow cytometry correlation was available in 150 cases. The ratio of males (62.5%) to females (37.5%) is 1.6:1. There was statistically significant difference in physical examination findings between AML and ALL patients. Splenomegaly, lymphadenopathy, and sternal tenderness were more often seen in ALL than in AML patients ( < 0.05). Pallor was more significantly associated with AML than with ALL patients ( < 0.05). Anemia and leucocytosis were found to be significantly associated with acute leukemia patients ( < 0.000). AML M2 was the most common subtype of AML, and B-ALL was the most common subtype of ALL cases.
由于缺乏基于人群的癌症登记（PBCR）数据和专业的三级癌症中心设施，比哈尔邦血液系统恶性肿瘤的实际发病率和人口统计学特征尚不清楚。本研究的目的是通过回顾性医疗记录来估计急性白血病病例的患病率、临床血液学特征和亚型。
在印度比哈尔邦巴特那英迪拉·甘地医学科学研究所血液科进行了一项为期2年的回顾性研究，时间从2019年7月至2021年6月。共有176例具有相关临床特征和血液学检查结果的病例纳入研究。对医疗记录进行研究并检索数据。
使用SPSS 25版记录和分析数据。
共有176例具有相关临床特征和血液学检查结果的病例纳入研究。急性髓系白血病（AML）最为常见（52.8%），其次是急性淋巴细胞白血病（ALL）（34.1%）和未分类的急性白血病病例（13.1%）。150例病例可进行流式细胞术相关性分析。男性（62.5%）与女性（37.5%）的比例为1.6:1。AML和ALL患者的体格检查结果存在统计学显著差异。ALL患者比AML患者更常出现脾肿大、淋巴结病和胸骨压痛（P<0.05）。面色苍白在AML患者中比在ALL患者中更显著相关（P<0.05）。贫血和白细胞增多症与急性白血病患者显著相关（P<0.000）。
AML M2是AML最常见的亚型，B-ALL是ALL病例最常见的亚型。
