Benavides-Aguilar Javier A, Morales-Rodríguez Jonathan I, Ambriz-González Héctor, Ruiz-Manriquez Luis M, Banerjee Antara, Pathak Surajit, Duttaroy Asim K, Paul Sujay
Tecnológico de Monterrey, School of Engineering and Sciences, Queretaro, Mexico.
Tecnologico de Monterrey, School of Medicine and Health Science, Monterrey, Mexico.
Front Genet. 2023 Mar 29;14:1152110. doi: 10.3389/fgene.2023.1152110. eCollection 2023.
MicroRNAs (miRNAs) are highly conserved, small non-coding RNA molecules (∼21 nucleotides) that regulate numerous biological processes, including developmental timing, hematopoiesis, organogenesis, apoptosis, cell differentiation, and proliferation either by mRNA degradation or translation repression. Since eye physiology requires a perfect orchestration of complex regulatory networks, an altered expression of key regulatory molecules such as miRNAs potentially leads to numerous eye disorders. In recent years, comprehensive progress has been made in demonstrating the precise roles of miRNAs, emphasizing their potential use in diagnostic and therapeutic purposes of chronic human diseases. Thus, this review explicitly illustrates the regulatory roles of miRNAs in four common eye disorders, such as cataract, glaucoma, macular degeneration, and uveitis, and their application in disease management.
微小RNA（miRNA）是高度保守的小型非编码RNA分子（约21个核苷酸），可通过mRNA降解或翻译抑制来调节众多生物学过程，包括发育时间、造血作用、器官发生、细胞凋亡、细胞分化和增殖。由于眼睛生理需要复杂调控网络的完美协调，miRNA等关键调控分子表达的改变可能导致多种眼部疾病。近年来，在证明miRNA的确切作用方面取得了全面进展，强调了它们在慢性人类疾病诊断和治疗中的潜在用途。因此，本综述明确阐述了miRNA在四种常见眼部疾病（如白内障、青光眼、黄斑变性和葡萄膜炎）中的调控作用及其在疾病管理中的应用。
