Hao Yongqiang, Cao Bojun, Deng Liang, Li Jiaxin, Ran Zhaoyang, Wu Junxiang, Pang Boran, Tan Jia, Luo Dinghao, Wu Wen
Clinical and Translational Research Center for 3D Printing Technology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Int J Bioprint. 2022 Dec 22;9(2):654. doi: 10.18063/ijb.v9i2.654. eCollection 2023.
The repair and reconstruction of bone defects are still major problems to be solved in the field of orthopedics. Meanwhile, 3D-bioprinted active bone implants may provide a new and effective solution. In this case, we used bioink prepared from the patient's autologous platelet-rich plasma (PRP) combined with polycaprolactone/β-tricalcium phosphate (PCL/β-TCP) composite scaffold material to print personalized PCL/β-TCP/PRP active scaffolds layer by layer through 3D bioprinting technology. The scaffold was then applied in the patient to repair and reconstruct bone defect after tibial tumor resection. Compared with traditional bone implant materials, 3D-bioprinted personalized active bone will have significant clinical application prospects due to its advantages of biological activity, osteoinductivity, and personalized design.
骨缺损的修复与重建仍是骨科领域有待解决的重大问题。与此同时，3D生物打印活性骨植入物可能提供一种新的有效解决方案。在此情况下，我们使用由患者自体富血小板血浆（PRP）与聚己内酯/β-磷酸三钙（PCL/β-TCP）复合支架材料制备的生物墨水，通过3D生物打印技术逐层打印个性化的PCL/β-TCP/PRP活性支架。然后将该支架应用于患者，以修复和重建胫骨肿瘤切除后的骨缺损。与传统骨植入材料相比，3D生物打印个性化活性骨因其具有生物活性、骨诱导性和个性化设计等优点，将具有显著的临床应用前景。
