Zaidi Norahidah, Haron Mohd Nizam, Komilus Connie Fay, Lananan Fathurrahman, Chew Ha Hou, Yaakub Nadzifah, Kari Asmad
School of Animal Science, Aquatic Science and Environment, Faculty of Bioresources and Food Industry, Universiti Sultan Zainal Abidin (UniSZA), 22200 Besut, Terengganu, Malaysia.
Trop Life Sci Res. 2023 Mar;34(1):241-259. doi: 10.21315/tlsr2023.34.1.13. Epub 2023 Mar 31.
Reproductive health and male fertility are closely related to dietary practices. In recent years, Malaysia has shown a lot of interest in using herbal plants as dietary supplements or in the treatment of numerous diseases. , commonly known as karas or gaharu, has recently gained attention for its potential to cure many diseases due to its pharmacological properties. However, studies on its effect on male fertility and reproductive organs are very scarce. This study was conducted to determine the effect of on male reproductive organs' weight (testis, epididymis, prostate gland and seminal vesicle) and sperm quality (sperm count, sperm morphology and sperm motility) in adult Sprague Dawley rats. Twenty-four male Sprague Dawley rats were allocated into four treatment groups; Control (C: 1 mL of distilled water, = 6), Treatment 1 (T1: 1 g /kg body weight, = 6), Treatment 2 (T2: 2 g /kg body weight, = 6) and Treatment 3 (T3: 3 g /kg body weight, = 6), respectively. Distilled water and were administered by oral gavage once daily for 28 days. The rats were euthanised on Day 29 for assessment of reproductive organs' weight and sperm quality. Result shows that weight of testis, epididymis, prostate gland, seminal vesicle and sperm motility did not differ ( > 0.05) among control and treated groups. A significant increase ( < 0.05) of sperm number (1.36 10) and a decrease ( < 0.05) in percentage of the abnormal sperm (8.17%) were observed in T1 group when compared to Control group. Incremental dosage of seemed to decrease number of sperm (T3: 0.78 10 < T1: 1.36 10 with < 0.05) and increase percentage of abnormal sperm (T3: 18.83% > T2: 12.17% > T1: 8.17% with < 0.05). In conclusion, the administration of either 1, 2 or 3 grams of did not alter the reproductive organs' weight and sperm motility. However, the higher concentration of consumed by the rats seemed to have detrimental effects on the number and morphology of sperm.
生殖健康和男性生育能力与饮食习惯密切相关。近年来，马来西亚对使用草药作为膳食补充剂或治疗多种疾病表现出浓厚兴趣。[草药名称]，俗称卡拉或伽罗，因其药理特性具有治愈多种疾病的潜力，最近受到关注。然而，关于其对男性生育能力和生殖器官影响的研究非常稀少。本研究旨在确定[草药名称]对成年斯普拉格 - 道利大鼠雄性生殖器官重量（睾丸、附睾、前列腺和精囊）和精子质量（精子数量、精子形态和精子活力）的影响。将24只雄性斯普拉格 - 道利大鼠分为四个治疗组；对照组（C：1毫升蒸馏水，n = 6）、治疗组1（T1：1克/千克体重，n = 6）、治疗组2（T2：2克/千克体重，n = 6）和治疗组3（T3：3克/千克体重，n = 6）。蒸馏水和[草药名称]通过口服灌胃每天给药一次，持续28天。在第29天对大鼠实施安乐死以评估生殖器官重量和精子质量。结果显示，对照组和治疗组之间睾丸、附睾、前列腺、精囊的重量以及精子活力没有差异（P>0.05）。与对照组相比，T1组观察到精子数量显著增加（P<0.05）（1.36×10），异常精子百分比降低（P<0.05）（8.17%）。[草药名称]剂量增加似乎会减少精子数量（T3：0.78×10<T1：1.36×10，P<0.05）并增加异常精子百分比（T3：18.83%>T2：12.17%>T1：8.17%，P<0.05）。总之，给予1克、2克或3克[草药名称]不会改变生殖器官重量和精子活力。然而，大鼠摄入较高浓度的[草药名称]似乎对精子数量和形态有不利影响。
