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热解吸原位分离的纳米机电红外光谱学：NEMS-IR-TD。

Nanoelectromechanical Infrared Spectroscopy with In Situ Separation by Thermal Desorption: NEMS-IR-TD.

机构信息

Institute of Sensor and Actuator Systems, TU Wien, Gusshausstrasse 27-29, 1040 Vienna, Austria.

Invisible-Light Labs GmbH, Taubstummengasse 11, 1040 Vienna, Austria.

出版信息

ACS Sens. 2023 Apr 28;8(4):1462-1470. doi: 10.1021/acssensors.2c02435. Epub 2023 Apr 17.

DOI:10.1021/acssensors.2c02435
PMID:37067504
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10152476/
Abstract

We present a novel method for the quantitative analysis of mixtures of semivolatile chemical compounds. For the first time, thermal desorption is integrated directly with nanoelectromechanical infrared spectroscopy (NEMS-IR-TD). In this new technique, an analyte mixture is deposited via nebulization on the surface of a NEMS sensor and subsequently desorbed using heating under vacuum. The desorption process is monitored via infrared spectroscopy and thermogravimetric analysis. The resulting spectro-temporal maps allow for selective identification and analysis of the mixture. In addition, the corresponding thermogravimetric data allow for analysis of the desorption dynamics of the mixture components. As a demonstration, caffeine and theobromine were selectively identified and quantified from a mixture with a detection limit of less than 6 pg (about 30 fmol). With its exceptional sensitivity, NEMS-IR-TD allows for the analysis of low abundance and complex analytes with potential applications ranging from environmental sensing to life sciences.

摘要

我们提出了一种分析半挥发性化合物混合物的新方法。这是首次将热解吸直接与纳机电红外光谱（NEMS-IR-TD）集成在一起。在这项新技术中，通过雾化将分析物混合物沉积在 NEMS 传感器的表面上，然后在真空中通过加热进行解吸。通过红外光谱和热重分析监测解吸过程。所得的光谱时间图谱可用于选择性识别和分析混合物。此外，相应的热重数据可用于分析混合物成分的解吸动力学。作为演示，从咖啡因和可可碱的混合物中选择性地鉴定和定量了咖啡因和可可碱，检测限低于 6 pg（约 30 fmol）。NEMS-IR-TD 具有极高的灵敏度，可用于分析低丰度和复杂的分析物，其潜在应用范围从环境传感到生命科学。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7133/10152476/e19c6998c35f/se2c02435_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7133/10152476/20b6e777651a/se2c02435_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7133/10152476/884365930fbf/se2c02435_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7133/10152476/8c89ef4d1b22/se2c02435_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7133/10152476/26db21f838fc/se2c02435_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7133/10152476/3014b3b5194b/se2c02435_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7133/10152476/e19c6998c35f/se2c02435_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7133/10152476/20b6e777651a/se2c02435_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7133/10152476/884365930fbf/se2c02435_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7133/10152476/8c89ef4d1b22/se2c02435_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7133/10152476/26db21f838fc/se2c02435_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7133/10152476/3014b3b5194b/se2c02435_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7133/10152476/e19c6998c35f/se2c02435_0006.jpg

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