Laboratory for Reproductive and Developmental Disorders, Department of Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab, Bathinda, 151401, India.
Department of Mathematics and Statistics, Central University of Punjab, Bathinda, 151401, India.
Biol Trace Elem Res. 2024 Jan;202(1):73-86. doi: 10.1007/s12011-023-03664-6. Epub 2023 Apr 17.
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrinological syndrome characterized by hyperandrogenism of ovarian origin and is often considered a predisposing factor for metabolic disorders. The objective of the study was to investigate serum levels of (a) trace elements (copper (Cu), zinc (Zn), magnesium (Mg), selenium (Se), iron (Fe), chromium (Cr), and manganese (Mn)); and (b) biochemical parameters (glucose, cholesterol, triglycerides, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), albumin, total protein, creatinine, and C-reactive protein (CRP) with risk of PCOS. Another objective was to explore the relationship between serum trace elements and biochemical variables. Serum trace elements were estimated by inductively coupled plasma mass spectrometry (ICP-MS) and biochemical parameters were estimated by colorimetric methods in 99 PCOS cases and 82 controls. Linear and non-linear associations of serum variables with PCOS risk were studied under logistic, probit, GAM, and BKMR model. Statistical analyses were performed using IBM SPSS 22.0 and R package version 4.2.1. All studied serum trace elements (except Zn) are significantly associated with PCOS. Combined effect analysis revealed Mg-Se and Fe-Cu association with PCOS risk. A significant association of cholesterol, HDL-C, LDL-C, CRP, and albumin was observed. Furthermore, linear regression analysis suggests an association between Mg-Cu and Mg-Fe-Mn with HDL-C; Fe and Cr-Cu with albumin; and Cu-Se with cholesterol and LDL-C both.
多囊卵巢综合征（PCOS）是一种异质性内分泌综合征，其特征为卵巢源性高雄激素血症，并且常被认为是代谢紊乱的一个诱发因素。本研究旨在探讨血清中（a）微量元素（铜（Cu）、锌（Zn）、镁（Mg）、硒（Se）、铁（Fe）、铬（Cr）和锰（Mn））；以及（b）生化参数（葡萄糖、胆固醇、甘油三酯、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、白蛋白、总蛋白、肌酐和 C 反应蛋白（CRP）与 PCOS 风险的关系。另一个目的是探讨血清微量元素与生化变量之间的关系。采用电感耦合等离子体质谱法（ICP-MS）测定血清微量元素，比色法测定生化参数，共纳入 99 例 PCOS 患者和 82 例对照者。采用逻辑斯蒂回归、概率单位回归、广义相加模型（GAM）和贝叶斯分层无向图模型（BKMR）研究血清变量与 PCOS 风险的线性和非线性关联。使用 IBM SPSS 22.0 和 R 包版本 4.2.1 进行统计分析。所有研究的血清微量元素（除 Zn 外）均与 PCOS 显著相关。合并效应分析显示 Mg-Se 和 Fe-Cu 与 PCOS 风险相关。胆固醇、HDL-C、LDL-C、CRP 和白蛋白也存在显著相关性。此外，线性回归分析表明 Mg-Cu 和 Mg-Fe-Mn 与 HDL-C 之间存在关联；Fe 和 Cr-Cu 与白蛋白有关；Cu-Se 与胆固醇和 LDL-C 有关。
