Department of Dietetics, Faculty of Physical Culture in Gorzów Wlkp., Poznan University of Physical Education, Estkowskiego 13, 66-400 Gorzów Wielkopolski, Poland.
Department of Perinatology and Gynecology, Division of Developmental Gynecology and Sexology, Poznan University of Medical Sciences, 60-535 Poznan, Poland.
Nutrients. 2021 Mar 10;13(3):896. doi: 10.3390/nu13030896.
The impact of diet on inflammation and oxidative stress (OS) in girls with polycystic ovary syndrome (PCOS) is unknown. Therefore, our study aimed to investigate, in PCOS girls, whether certain macronutrient intakes can be associated with these disturbances. For this purpose, 59 PCOS participants (aged 14-18 years) were recruited to this study and divided into two subgroups: overweight/obese-Ov/Ob group ( = 22) and normal weight-N group ( = 37). Nutrition was assessed using a 3-day food record. The studied markers were total antioxidant capacity (TAC), malondialdehyde (MDA), C-reactive protein (CRP), tumor necrosis factor α (TNF-α), and interleukins 1 and 6 (IL-1 and IL-6). We found plant protein intake inversely correlated with IL-6 ( = 0.007; = -0.557), TNF-α ( = 0.006; = -0.564), MDA ( = 0.01; = -0.539) in the Ov/Ob group and with TAC ( = 0.021; = -0.38) in the N group. Inverse correlations in the Ov/Ob group were observed between protein intake and IL-6 ( = 0.031; = -0.461), TNF- α ( = 0.043; = -0.435); carbohydrates and IL-6 ( = 0.037; = -0.448), MDA ( = 0.045; = -0.431); fiber and IL-6 ( = 0.025; = -0.475). A positive relationship between cholesterol intake and CRP concentration ( = 0.038; = 0.342) was also found in the N group. These findings revealed that inflammation and OS are increased in Ov/Ob girls with decreased plant protein intake and low carbohydrates in the diet. Moreover, inflammation may be increased by cholesterol intake in slim PCOS girls. On the other hand, decreased intake of fiber and total protein intake increased inflammation. ClinicalTrials.gov Identifier: NCT04738409.
饮食对多囊卵巢综合征（PCOS）女孩的炎症和氧化应激（OS）的影响尚不清楚。因此，我们的研究旨在调查 PCOS 女孩中某些宏量营养素的摄入是否与这些紊乱有关。为此，本研究招募了 59 名 PCOS 参与者（年龄 14-18 岁），并将其分为两个亚组：超重/肥胖-Ov/Ob 组（=22）和正常体重-N 组（=37）。使用 3 天的食物记录来评估营养状况。研究的标志物是总抗氧化能力（TAC）、丙二醛（MDA）、C 反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）和白细胞介素 1 和 6（IL-1 和 IL-6）。我们发现，植物蛋白摄入与 Ov/Ob 组的 IL-6（=0.007；=-0.557）、TNF-α（=0.006；=-0.564）和 MDA（=0.01；=-0.539）呈负相关，与 N 组的 TAC（=0.021；=-0.38）呈负相关。在 Ov/Ob 组中，还观察到蛋白质摄入与 IL-6（=0.031；=-0.461）、TNF-α（=0.043；=-0.435）呈负相关；碳水化合物与 IL-6（=0.037；=-0.448）和 MDA（=0.045；=-0.431）呈负相关；纤维与 IL-6（=0.025；=-0.475）呈负相关。在 N 组中，胆固醇摄入与 CRP 浓度（=0.038；=0.342）之间也存在正相关关系。这些发现表明，饮食中植物蛋白摄入减少和碳水化合物含量低会导致 Ov/Ob 女孩的炎症和 OS 增加。此外，胆固醇摄入可能会增加瘦型 PCOS 女孩的炎症。另一方面，膳食纤维和总蛋白摄入减少会增加炎症。ClinicalTrials.gov 标识符：NCT04738409。
