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用于慢性胰腺炎的去神经支配脾胰瓣

Denervated splenopancreatic flap for chronic pancreatitis.

作者信息

Shires G T, Warren W D, Millikan W J, Henderson J M, Hersh T

出版信息

Ann Surg. 1986 May;203(5):568-73. doi: 10.1097/00000658-198605000-00018.

Abstract

Various surgical procedures have addressed the disabling pain of chronic pancreatitis. Pain control must be weighed against the surgical morbidity and metabolic consequences of operation. Although ductal drainage works well for patients with dilated ducts, a new procedure was devised to avoid the diabetic morbidity of near-total pancreatectomy or pancreaticoduodenectomy in patients with small duct pancreatitis. Five patients have undergone the splenopancreatic flap procedure. The head of the pancreas is resected in a manner similar to near-total pancreatectomy, while the body and tail are denervated by dissection from their bed, with retrograde perfusion from the splenic hilus. All patients are alive a mean of 9 months after operation, and none is diabetic. Only one patient requires narcotic analgesics. Although none is asymptomatic, all have shown significant weight gain, and four of five are vocationally rehabilitated. Flap viability and the absence of transgastric varices have been documented by angiography and CT scanning. Although the durability of pain relief and islet cell function is unknown, these results suggest that this procedure may offer an alternative to major resection in chronic pancreatitis.

摘要

多种外科手术方法已用于治疗慢性胰腺炎所致的致残性疼痛。必须在控制疼痛与手术的发病率及代谢后果之间进行权衡。尽管导管引流术对胰管扩张的患者效果良好,但针对小胰管型胰腺炎患者,设计了一种新手术,以避免近乎全胰切除术或胰十二指肠切除术所带来的糖尿病发病风险。5例患者接受了脾胰瓣手术。胰腺头部的切除方式类似于近乎全胰切除术,而胰体和胰尾则通过从其床面进行解剖去神经支配,并通过脾门逆行灌注。所有患者术后平均存活9个月,且均未患糖尿病。只有1例患者需要使用麻醉性镇痛药。尽管无人无症状,但所有人均体重显著增加,5例中有4例恢复了工作。血管造影和CT扫描已证实皮瓣存活且无经胃静脉曲张。尽管疼痛缓解和胰岛细胞功能的持久性尚不清楚,但这些结果表明,该手术可能为慢性胰腺炎的大手术切除提供一种替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f2d/1251173/34ba9997c7b8/annsurg00099-0130-a.jpg

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