State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Qingdao Municipal Center for Disease Control and Prevention, Qingdao Institute of Prevention Medicine, Qingdao, Shandong Province, China.
Microbiol Spectr. 2023 Jun 15;11(3):e0534022. doi: 10.1128/spectrum.05340-22. Epub 2023 Apr 19.
Tick-borne viruses (TBVs) have attracted increasingly global public health attention. In this study, the viral compositions of five tick species, Haemaphysalis flava, Rhipicephalus sanguineus, Dermacentor sinicus, Haemaphysalis longicornis, and Haemaphysalis campanulata, from hedgehogs and hares in Qingdao, China, were profiled via metagenomic sequencing. Thirty-six strains of 10 RNA viruses belonging to 4 viral families, including 3 viruses of , 4 viruses of , 2 viruses of , and 1 virus of , were identified in five tick species. Three novel viruses of two families, namely, Qingdao tick iflavirus (QDTIFV) of the family of and Qingdao tick phlebovirus (QDTPV) and Qingdao tick uukuvirus (QDTUV) of the family of , were found in this study. This study shows that ticks from hares and hedgehogs in Qingdao harbored diverse viruses, including some that can cause emerging infectious diseases, such as Dabie bandavirus. Phylogenetic analysis revealed that these tick-borne viruses were genetically related to viral strains isolated previously in Japan. These findings shed new light on the cross-sea transmission of tick-borne viruses between China and Japan. Thirty-six strains of 10 RNA viruses belonging to 4 viral families, including 3 viruses of , 4 viruses of , 2 viruses of , and 1 virus of , were identified from five tick species in Qingdao, China. A diversity of tick-borne viruses from hares and hedgehogs in Qingdao was found in this study. Phylogenetic analysis showed that most of these TBVs were genetically related to Japanese strains. These findings indicate the possibility of the cross-sea transmission of TBVs between China and Japan.
在中国青岛的刺猬和野兔身上，通过宏基因组测序发现了 5 种蜱虫（黄热病、血红扇头蜱、中华革蜱、长角血蜱和三棘血蜱）中的 36 株 10 种 RNA 病毒，隶属于 4 个病毒科，包括 3 种病毒科、4 种病毒科、2 种病毒科和 1 种病毒科。在本研究中发现了两种新的病毒科，即属于病毒科的青岛 tick iflavirus（QDTIFV）和属于病毒科的青岛 tick phlebovirus（QDTPV）和青岛 tick uukuvirus（QDTUV）。本研究表明，青岛刺猬和野兔身上的蜱虫携带多种病毒，包括一些可能导致新发传染病的病毒，如大别山病毒。系统进化分析显示，这些蜱传病毒与之前在日本分离的病毒株在基因上具有亲缘关系。这些发现为中国和日本之间的蜱传病毒跨海传播提供了新的视角。
