Key Laboratory of Efficient Utilization of Non-grain Feed Resources, Department of Animal Science, Shandong Agricultural University, Taian, Shandong, China; Precision Livestock and Nutrition Unit, Gembloux Agro-Bio Tech, University of Liège, Gembloux, Belgium.
Key Laboratory of Efficient Utilization of Non-grain Feed Resources, Department of Animal Science, Shandong Agricultural University, Taian, Shandong, China.
Poult Sci. 2023 Jun;102(6):102658. doi: 10.1016/j.psj.2023.102658. Epub 2023 Mar 18.
This study aimed to investigate the effects of dietary sodium butyrate (SB) supplementation on the reproductive performance of female broiler breeders under intensive rearing conditions and to analyze antioxidant capacity, immune function, and intestinal barrier function of the female breeders and their offspring. A total of 96,000 40-wk-old Ross308 female broiler breeders were divided into the control (CON) and SB groups, each with 6 replicates of 8,000 birds. Each house with similar production performance characteristics was considered a replicate. The experiment lasted for 20 wk, whereupon sampling took place. Results showed that SB improved the egg production performance, egg quality of broiler breeders, and hatchability (P < 0.05). Maternal supplementation with SB substantially increased serum immunoglobulin A levels in broiler breeders and offspring (both P = 0.04) and offspring immunoglobulin G (P < 0.001). The levels of interleukin-1β (P < 0.001) and interleukin-4 (P = 0.03) in the offspring were downregulated, while the total superoxide dismutase in the offspring and the eggs increased (P < 0.05). The serum biochemical components in breeders and offspring were altered by SB, as evidenced by the reduction in triglycerides, total cholesterol, and high- and low-density lipoproteins (P < 0.05). The intestinal morphology of broiler breeders and offspring also improved by the SB with the decreasing the jejunal crypt depth (P = 0.04) and increasing villus height in offspring (P = 0.03). Maternal jejunal and ileal intestinal barrier-related genes were also shown to be significantly affected by SB. Furthermore, SB altered the microbial diversity in maternal cecal contents, thus increasing the abundance of Lachnospiraceae (P = 0.004) and Ruminococcaceae (P = 0.03). Dietary SB enhanced the reproductive performance and egg quality of broiler breeders and improved the antioxidant capacity and immune function of broiler breeders and offspring, with the benefits potentially arising from the regulation of the maternal intestinal barrier and gut microbiota by SB.
本研究旨在探讨饲粮丁酸钠（SB）添加对集约化饲养条件下肉种鸡繁殖性能的影响，并分析母代肉种鸡及其后代的抗氧化能力、免疫功能和肠道屏障功能。选用 96000 只 40 周龄的 Ross308 肉种鸡，随机分为对照组（CON）和 SB 组，每组 6 个重复，每个重复 8000 只鸡。每个鸡舍具有相似的生产性能特征，视为一个重复。试验持续 20 周，然后采样。结果表明，SB 提高了肉种鸡的产蛋性能、蛋品质和孵化率（P＜0.05）。母代 SB 补充显著提高了肉种鸡及其后代的血清免疫球蛋白 A 水平（均 P＜0.05）和后代的免疫球蛋白 G（P＜0.001）。后代白细胞介素-1β（P＜0.001）和白细胞介素-4（P=0.03）水平降低，后代和鸡蛋中超氧化物歧化酶总量增加（P＜0.05）。SB 改变了肉种鸡及其后代的血清生化成分，表现为甘油三酯、总胆固醇和高低密度脂蛋白降低（P＜0.05）。SB 还改善了肉种鸡及其后代的肠道形态，表现为降低了空肠隐窝深度（P=0.04）和增加了后代的绒毛高度（P=0.03）。母代空肠和回肠肠屏障相关基因也受到 SB 的显著影响。此外，SB 改变了母代盲肠内容物中的微生物多样性，从而增加了 Lachnospiraceae（P=0.004）和 Ruminococcaceae（P=0.03）的丰度。饲粮 SB 增强了肉种鸡的繁殖性能和蛋品质，提高了肉种鸡及其后代的抗氧化能力和免疫功能，其益处可能来自 SB 对母代肠道屏障和肠道微生物群的调节。
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