Draelos Zoe Diana, McDaniel David H, Yoelin Steve, Pot Sera, Sotir Olivia, Nelson Diane B
Dr. Draelos is with Dermatology Consulting Services, PLLC in High Point, North Carolina.
Dr. McDaniel is with McDaniel Institute of Aging Research in Virginia Beach, Virginia.
J Clin Aesthet Dermatol. 2023 Apr;16(4):53-59.
Evaluate the effects of a new antioxidant containing topical allyl pyrroloquinoline quinone (TAP) on expression of key markers and assess the efficacy and tolerability in subjects with photodamaged skin.
Donor skin tissue was irradiated prior to and following application of study products (TAP; a leading antioxidant cream [L-VC]). Expression of markers related to epidermal homeostasis and oxidative stress were assessed at 48 hours and compared to untreated, irradiated control (n=3 each). Evaluation of lines/wrinkles, skin texture, skin tone, dullness, and erythema from baseline occurred over 12 weeks in subjects with mild-to-moderate photodamaged skin. Histological evaluation occurred at Weeks 6 and 12 (n=4).
Following application of TAP, significant expression of markers related to epidermal homeostasis and repair, recycling and removal, and oxidative stress were demonstrated, compared to control (<0.05). Reduced expression of collagen degrading enzymes, compared to control, were observed (<0.05). Application of L-VC demonstrated nonsignificant expression of markers versus control. In 40 subjects evaluated over 12 weeks, significant mean improvements from baseline were observed at Week 4 in skin texture and dullness (both <0.0001) and skin tone and lines/wrinkles (both =0.01). The study product was highly tolerable. Histologic evaluation demonstrated reductions in solar elastosis from baseline at Weeks 6 (33%, =0.01) and 12 (60%, =0.002).
An antioxidant containing TAP addresses internal and external manifestations of photoaging. TAP demonstrated significant expression of key markers associated with epidermal homeostasis and counteracting oxidative stress. Significant, early improvements in the appearance of photodamaged skin and histological improvements in solar elastosis were observed.
评估一种含有局部用烯丙基吡咯喹啉醌（TAP）的新型抗氧化剂对关键标志物表达的影响，并评估其在光损伤皮肤受试者中的疗效和耐受性。
在应用研究产品（TAP；一种领先的抗氧化霜 [L-VC]）之前和之后对供体皮肤组织进行照射。在48小时时评估与表皮稳态和氧化应激相关的标志物的表达，并与未处理的照射对照（每组n=3）进行比较。在轻度至中度光损伤皮肤的受试者中，在12周内从基线开始评估皱纹、皮肤质地、肤色、暗沉和红斑。在第6周和第12周进行组织学评估（n=4）。
与对照组相比，应用TAP后，与表皮稳态和修复、循环和清除以及氧化应激相关的标志物有显著表达（<0.05）。与对照组相比，观察到胶原蛋白降解酶的表达降低（<0.05）。与对照组相比，L-VC的应用显示标志物表达无显著差异。在12周内评估的40名受试者中，在第4周时观察到皮肤质地和暗沉（均<0.0001）以及肤色和皱纹（均=0.01）相对于基线有显著的平均改善。该研究产品具有高度耐受性。组织学评估显示，在第6周（33%，=0.01）和第12周（60%，=0.002）时，日光性弹力纤维变性相对于基线有所减少。
一种含有TAP的抗氧化剂可解决光老化的内部和外部表现。TAP显示出与表皮稳态和对抗氧化应激相关的关键标志物的显著表达。观察到光损伤皮肤外观有显著的早期改善以及日光性弹力纤维变性有组织学改善。
