Levack I D, Holmes J D, Robertson G S
Br J Anaesth. 1986 Jun;58(6):615-9. doi: 10.1093/bja/58.6.615.
In a double-blind trial, 50 patients with subcostal incisions performed for cholecystectomy or splenectomy, received 10 ml of either 0.5% bupivacaine plain or physiological saline twice daily by wound perfusion through an indwelling drainage tube for 3 days after operation. Analgesia, assessed by visual analogue score (VAS) and forced vital capacity (FVC), was significantly improved after perfusion with bupivacaine. Perfusion with physiological saline produced an analgesic effect comparable to that of bupivacaine as indicated by improvement in VAS. There was, however, no improvement in FVC, and opioid requirements were greater, in the patients whose wounds had been perfused with saline.
在一项双盲试验中，50例行胆囊切除术或脾切除术并采用肋下切口的患者，在术后3天通过留置引流管每天两次向伤口灌注10毫升0.5%布比卡因原液或生理盐水。通过视觉模拟评分法（VAS）和用力肺活量（FVC）评估镇痛效果，结果显示布比卡因灌注后镇痛效果显著改善。VAS改善情况表明，生理盐水灌注产生的镇痛效果与布比卡因相当。然而，生理盐水灌注组患者的FVC无改善，且阿片类药物需求量更大。
