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Enhancing prime editing efficiency and flexibility with tethered and split pegRNAs.

作者信息

Feng Ying, Liu Siyuan, Mo Qiqin, Liu Pengpeng, Xiao Xiao, Ma Hanhui

机构信息

Gene Editing Center, School of Life Science and Technology, ShanghaiTech University, Shanghai 200135, China.

School of Biotechnology, East China University of Science and Technology, Shanghai 200237, China.

出版信息

Protein Cell. 2023 Apr 21;14(4):304-308. doi: 10.1093/procel/pwac014.

DOI:10.1093/procel/pwac014
PMID:37078887
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10120949/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d1/10120949/fe8e60ce223f/pwac014_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d1/10120949/15847da28cdd/pwac014_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d1/10120949/fe8e60ce223f/pwac014_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d1/10120949/15847da28cdd/pwac014_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58d1/10120949/fe8e60ce223f/pwac014_fig2.jpg

相似文献

[1]
Enhancing prime editing efficiency and flexibility with tethered and split pegRNAs.

Protein Cell. 2023-4-21

[2]
Correction to: Enhancing prime editing efficiency and flexibility with tethered and split pegRNAs.

Protein Cell. 2024-2-1

[3]
Optimized prime editing efficiently generates heritable mutations in maize.

J Integr Plant Biol. 2023-4

[4]
Author Correction: Engineered pegRNAs improve prime editing efficiency.

Nat Biotechnol. 2022-3

[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
CRISPR/Cas9 in colorectal cancer: Revolutionizing precision oncology through genome editing and targeted therapeutics.

Iran J Basic Med Sci. 2025

[2]
Circular RNA-mediated inverse prime editing in human cells.

Nat Commun. 2025-5-31

[3]
Systematic optimization of prime editing for enhanced efficiency and versatility in genome engineering across diverse cell types.

Front Cell Dev Biol. 2025-4-29

[4]
Advancing Precision Medicine: Recent Innovations in Gene Editing Technologies.

Adv Sci (Weinh). 2025-4

[5]
Prime Editing: A Revolutionary Technology for Precise Treatment of Genetic Disorders.

Cell Prolif. 2025-4

[6]
Prime Editing: Mechanistic Insights and DNA Repair Modulation.

Cells. 2025-2-13

[7]
EXPERT expands prime editing efficiency and range of large fragment edits.

Nat Commun. 2025-2-13

[8]
Mismatch prime editing gRNA increased efficiency and reduced indels.

Nat Commun. 2025-1-2

[9]
From bench to bedside: cutting-edge applications of base editing and prime editing in precision medicine.

J Transl Med. 2024-12-20

[10]
Strategies for improving the genome-editing efficiency of class 2 CRISPR/Cas system.

Heliyon. 2024-9-27

本文引用的文献

[1]
Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing.

Nat Biotechnol. 2022-5

[2]
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.

Cell. 2021-10-28

[3]
Precise genomic deletions using paired prime editing.

Nat Biotechnol. 2022-2

[4]
Engineered pegRNAs improve prime editing efficiency.

Nat Biotechnol. 2022-3

[5]
Enhancing prime editing by Csy4-mediated processing of pegRNA.

Cell Res. 2021-10

[6]
Prime genome editing in rice and wheat.

Nat Biotechnol. 2020-3-16

[7]
Search-and-replace genome editing without double-strand breaks or donor DNA.

Nature. 2019-10-21

[8]
Highly efficient expression of circular RNA aptamers in cells using autocatalytic transcripts.

Nat Biotechnol. 2019-4-8

[9]
CRISPR-Sirius: RNA scaffolds for signal amplification in genome imaging.

Nat Methods. 2018-10-30

[10]
Repair of double-strand breaks induced by CRISPR-Cas9 leads to large deletions and complex rearrangements.

Nat Biotechnol. 2018-7-16

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