Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Osteoporosis Centre, Centre for Bone and Arthritis Research at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Nat Commun. 2023 Apr 20;14(1):2250. doi: 10.1038/s41467-023-37978-9.
Appendicular lean mass (ALM) associates with mobility and bone mineral density (BMD). While associations between gut microbiota composition and ALM have been reported, previous studies rely on relatively small sample sizes. Here, we determine the associations between prevalent gut microbes and ALM in large discovery and replication cohorts with information on relevant confounders within the population-based Norwegian HUNT cohort (n = 5196, including women and men). We show that the presence of three bacterial species - Coprococcus comes, Dorea longicatena, and Eubacterium ventriosum - are reproducibly associated with higher ALM. When combined into an anabolic species count, participants with all three anabolic species have 0.80 kg higher ALM than those without any. In an exploratory analysis, the anabolic species count is positively associated with femoral neck and total hip BMD. We conclude that the anabolic species count may be used as a marker of ALM and BMD. The therapeutic potential of these anabolic species to prevent sarcopenia and osteoporosis needs to be determined.
肢体瘦体重（ALM）与活动能力和骨密度（BMD）相关。虽然已经报道了肠道微生物组成与 ALM 之间的关联，但以前的研究依赖于相对较小的样本量。在这里，我们在基于人群的挪威 HUNT 队列中（n=5196，包括女性和男性），在具有相关混杂因素的信息的大型发现和复制队列中，确定了常见肠道微生物与 ALM 之间的关联。我们表明，三种细菌物种——Coprococcus comes、Dorea longicatena 和 Eubacterium ventriosum 的存在与更高的 ALM 具有可重复性。当将它们组合成一个合成代谢物种计数时，具有所有三种合成代谢物种的参与者的 ALM 比没有任何一种的参与者高 0.80 公斤。在探索性分析中，合成代谢物种计数与股骨颈和全髋 BMD 呈正相关。我们得出结论，合成代谢物种计数可用作 ALM 和 BMD 的标志物。这些合成代谢物种预防肌肉减少症和骨质疏松症的治疗潜力需要确定。
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