Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea.
Department of Pathophysiology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Aging Cell. 2024 Oct;23(10):e14315. doi: 10.1111/acel.14315. Epub 2024 Aug 15.
The intricate interplay between cellular senescence and alterations in the gut microbiome emerges as a pivotal axis in the aging process, increasingly recognized for its contribution to systemic inflammation, physiological decline, and predisposition to age-associated diseases. Cellular senescence, characterized by a cessation of cell division in response to various stressors, induces morphological and functional changes within tissues. The complexity and heterogeneity of senescent cells, alongside the secretion of senescence-associated secretory phenotype, exacerbate the aging process through pro-inflammatory pathways and influence the microenvironment and immune system. Concurrently, aging-associated changes in gut microbiome diversity and composition contribute to dysbiosis, further exacerbating systemic inflammation and undermining the integrity of various bodily functions. This review encapsulates the burgeoning research on the reciprocal relationship between cellular senescence and gut dysbiosis, highlighting their collective impact on age-related musculoskeletal diseases, including osteoporosis, sarcopenia, and osteoarthritis. It also explores the potential of modulating the gut microbiome and targeting cellular senescence as innovative strategies for healthy aging and mitigating the progression of aging-related conditions. By exploring targeted interventions, including the development of senotherapeutic drugs and probiotic therapies, this review aims to shed light on novel therapeutic avenues. These strategies leverage the connection between cellular senescence and gut microbiome alterations to advance aging research and development of interventions aimed at extending health span and improving the quality of life in the older population.
细胞衰老与肠道微生物组改变之间的复杂相互作用，成为衰老过程中的关键轴，越来越多的研究表明其与系统性炎症、生理衰退以及与年龄相关疾病的易感性有关。细胞衰老的特征是细胞在受到各种应激后停止分裂，导致组织内形态和功能发生变化。衰老细胞的复杂性和异质性，以及衰老相关分泌表型的分泌，通过促炎途径加剧衰老过程，并影响微环境和免疫系统。同时，肠道微生物组多样性和组成的衰老相关变化导致菌群失调，进一步加剧系统性炎症并破坏各种身体功能的完整性。这篇综述总结了细胞衰老与肠道菌群失调之间互惠关系的新兴研究，强调了它们对与年龄相关的肌肉骨骼疾病（包括骨质疏松症、肌少症和骨关节炎）的共同影响。它还探讨了调节肠道微生物组和靶向细胞衰老作为健康衰老和减缓与年龄相关疾病进展的创新策略的潜力。通过探索靶向干预措施，包括开发衰老治疗药物和益生菌疗法，本综述旨在为新的治疗途径提供思路。这些策略利用了细胞衰老与肠道微生物组改变之间的联系，推进衰老研究和干预措施的发展，旨在延长健康寿命并提高老年人群的生活质量。
