Division of Neurology, Department of Medicine, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
University of Ottawa, School of Epidemiology, Ottawa, Ontario, Canada.
Cancer Med. 2023 Jun;12(11):12518-12523. doi: 10.1002/cam4.5964. Epub 2023 Apr 21.
The objective of this study was to examine the effect modification of age on the relationship between cancer and prevalence of self-reported stroke. We used cross-sectional data from the 2015-2016 iteration of the Canadian Community Health Survey. A multivariable logistic regression model was used to assess the association between cancer and self-reported stroke. Covariates were assessed for effect modification using the maximum likelihood estimation method. We analyzed 86,809 subjects; the prevalence of self-reported stroke was 1.11%. The odds ratio for the association between cancer and self-reported stroke was 1.26 (95% CI 0.98-1.61) after adjusting for age, sex, dyslipidemia, hypertension, diabetes, heart disease, education, and household income. Age and hypertension were found to be effect modifiers, and the association between cancer and self-reported stroke was stronger in younger adults and in those without hypertension. These results suggest that cancer-associated strokes may have unique underlying mechanisms compared to conventional strokes.
本研究旨在探讨年龄对癌症与自报告卒中患病率之间关系的修饰作用。我们使用了来自 2015-2016 年加拿大社区健康调查的横断面数据。采用多变量逻辑回归模型评估癌症与自报告卒中之间的关联。采用最大似然估计法评估协变量的修饰作用。我们分析了 86809 名受试者；自报告卒中的患病率为 1.11%。在调整年龄、性别、血脂异常、高血压、糖尿病、心脏病、教育程度和家庭收入后，癌症与自报告卒中之间的关联比值比为 1.26（95%CI 0.98-1.61）。年龄和高血压被发现是修饰因素，癌症与自报告卒中之间的关联在年轻成年人和无高血压人群中更强。这些结果表明，与传统卒中相比，癌症相关的卒中可能具有独特的潜在机制。
