Oxidative Stress and Antioxidant Laboratory, Postgraduate Program in Biotechnology, University of Caxias Do Sul, Caxias do Sul, Brazil.
The Human Performance Mechanic, Lehman College, New York, NY, United States of America.
PLoS One. 2023 Apr 21;18(4):e0283237. doi: 10.1371/journal.pone.0283237. eCollection 2023.
The purpose of this review was to analyze the acute effects of low-load resistance exercise with blood flow restriction (LLE-BFR) on oxidative stress markers in healthy individuals in comparison with LLE or high-load resistance exercise (HLRE) without BFR.
A systematic review was performed in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. These searches were performed in CENTRAL, SPORTDiscus, EMBASE, PubMed, CINAHL and Virtual Health Library- VHL, which includes Lilacs, Medline and SciELO. The risk of bias and quality of evidence were assessed through the PEDro scale and GRADE system, respectively.
Thirteen randomized clinical trials were included in this review (total n = 158 subjects). Results showed lower post-exercise damage to lipids (SMD = -0.95 CI 95%: -1.49 to -0. 40, I2 = 0%, p = 0.0007), proteins (SMD = -1.39 CI 95%: -2.11 to -0.68, I2 = 51%, p = 0.0001) and redox imbalance (SMD = -0.96 CI 95%: -1.65 to -0.28, I2 = 0%, p = 0.006) in favor of LLRE-BFR compared to HLRE. HLRE presents higher post-exercise superoxide dismutase activity but in the other biomarkers and time points, no significant differences between conditions were observed. For LLRE-BFR and LLRE, we found no difference between the comparisons performed at any time point.
Based on the available evidence from randomized trials, providing very low or low certainty of evidence, this review demonstrates that LLRE-BFR promotes less oxidative stress when compared to HLRE but no difference in levels of oxidative damage biomarkers and endogenous antioxidants between LLRE.
Register number: PROSPERO number: CRD42020183204.
本综述的目的是分析与无血流限制的低负荷阻力运动（LLRE）或高负荷阻力运动（HLRE）相比，低负荷阻力运动结合血流限制（LLE-BFR）对健康个体的急性氧化应激标志物的影响。
根据 PRISMA（系统评价和荟萃分析的首选报告项目）指南进行系统评价。这些搜索在 CENTRAL、SPORTDiscus、EMBASE、PubMed、CINAHL 和虚拟健康图书馆- VHL 中进行，其中包括 Lilacs、Medline 和 SciELO。通过 PEDro 量表和 GRADE 系统分别评估偏倚风险和证据质量。
本综述纳入了 13 项随机临床试验（共纳入 158 名受试者）。结果表明，与 HLRE 相比，LLRE-BFR 运动后脂质（SMD=-0.95，95%CI：-1.49 至-0.40，I2=0%，p=0.0007）、蛋白质（SMD=-1.39，95%CI：-2.11 至-0.68，I2=51%，p=0.0001）和氧化还原失衡（SMD=-0.96，95%CI：-1.65 至-0.28，I2=0%，p=0.006）的损伤更小。HLRE 运动后超氧化物歧化酶活性更高，但在其他生物标志物和时间点，两种条件之间无显著差异。对于 LLRE-BFR 和 LLRE，在任何时间点进行的比较中均未发现差异。
基于来自随机试验的现有证据，本综述提供了非常低或低确定性的证据，证明与 HLRE 相比，LLRE-BFR 可减少氧化应激，但 LLRE 之间的氧化损伤生物标志物和内源性抗氧化剂水平无差异。
注册号：PROSPERO 编号：CRD42020183204。
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