Provincial University Key Laboratory of Sport and Health Science, Provincial Key Laboratory for Developmental Biology and Neurosciences, Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, School of Physical Education and Sport Sciences, Fujian Normal University, Fuzhou 350007, China.
Oxid Med Cell Longev. 2021 Oct 1;2021:3846122. doi: 10.1155/2021/3846122. eCollection 2021.
Oxidative stress is the imbalance of the redox system in the body, which produces excessive reactive oxygen species, leads to multiple cellular damages, and closely relates to some pathological conditions, such as insulin resistance and inflammation. Meanwhile, exercise as an external stimulus of oxidative stress causes the changes of pathophysiological functions in the tissues and organs, including skeletal muscle. Exercise-induced oxidative stress is considered to have different effects on the structure and function of skeletal muscle. Long-term regular or moderate exercise-induced oxidative stress is closely related to the formation of muscle adaptation, while excessive free radicals produced by strenuous or acute exercise can cause muscle oxidative stress fatigue and damage, which impacts exercise capacity and damages the body's health. The present review systematically summarizes the relationship between exercise-induced oxidative stress and the adaptions, damage, and fatigue in skeletal muscle, in order to clarify the effects of exercise-induced oxidative stress on the pathophysiological functions of skeletal muscle.
氧化应激是指体内氧化还原系统失衡，产生过多的活性氧自由基，导致多种细胞损伤，与胰岛素抵抗、炎症等一些病理状况密切相关。同时，运动作为氧化应激的外部刺激，会引起组织和器官的病理生理功能变化，包括骨骼肌。运动引起的氧化应激被认为对骨骼肌的结构和功能有不同的影响。长期规律或适度的运动引起的氧化应激与肌肉适应的形成密切相关，而剧烈或急性运动产生的过多自由基会导致肌肉氧化应激疲劳和损伤，从而影响运动能力和损害身体健康。本综述系统总结了运动引起的氧化应激与骨骼肌适应、损伤和疲劳的关系，以阐明运动引起的氧化应激对骨骼肌病理生理功能的影响。
