Key Laboratory of Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
ACS Biomater Sci Eng. 2023 May 8;9(5):2470-2482. doi: 10.1021/acsbiomaterials.3c00039. Epub 2023 Apr 21.
In daily life and during surgery, the skin, as the outermost organ of the human body, is easily damaged to form wounds. If the wound was infected by the bacteria, especially the drug-resistant bacteria such as methicillin-resistant staphylococcus aureus (MRSA), it was difficult to recover. Therefore, it was important to develop the safe antimicrobial strategy to inhibit bacterial growth in the wound site, in particular, to overcome the problem of bacterial drug resistance. Here, the Ag/AgBr-loaded mesoporous bioactive glass (Ag/AgBr-MBG) was prepared, which had excellent photocatalytic properties under simulated daylight for rapid antibacterial activity within 15 min by generating reactive oxygen species (ROS). Meanwhile, the killing rate of Ag/AgBr-MBG against MRSA was 99.19% within 15 min, which further reduced the generation of drug-resistant bacteria. In addition, Ag/AgBr-MBG particles could disrupt bacterial cell membranes, showing the broad-spectrum antibacterial properties and promoting tissue regeneration and infected wound healing. Ag/AgBr-MBG particles might have potential applications as a light-driven antimicrobial agent in the field of biomaterials.
在日常生活和手术中，皮肤作为人体最外层的器官，很容易受到损伤形成伤口。如果伤口受到细菌感染，特别是耐甲氧西林金黄色葡萄球菌（MRSA）等耐药菌的感染，就很难恢复。因此，开发安全的抗菌策略来抑制伤口部位的细菌生长非常重要，特别是要克服细菌耐药性的问题。在这里，制备了负载 Ag/AgBr 的介孔生物活性玻璃（Ag/AgBr-MBG），它在模拟日光下具有优异的光催化性能，能够在 15 分钟内通过产生活性氧（ROS）快速实现抗菌活性。同时，Ag/AgBr-MBG 对 MRSA 的杀灭率在 15 分钟内达到 99.19%，进一步减少了耐药菌的产生。此外，Ag/AgBr-MBG 颗粒能够破坏细菌细胞膜，表现出广谱抗菌特性，并促进组织再生和感染伤口愈合。Ag/AgBr-MBG 颗粒有望作为一种光驱动抗菌剂在生物材料领域得到应用。
