Inchingolo A M, Gargiulo Isacco C, Inchingolo A D, Nguyen K C D, Cantore S, Santacroce L, Scacco S, Cirulli N, Corriero A, Puntillo F, Dipalma G, Ballini A, Inchingolo F
Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy.
Eur Rev Med Pharmacol Sci. 2023 Mar;27(6):2659-2670. doi: 10.26355/eurrev_202303_31803.
Data collection has suggested a complex correlation between the gut microbiota (GM) and bone homeostasis involving host-microbiota crosstalk. Although the GM is known to affect bone metabolism, the mechanisms linked with these effects remain unclear. The aim of this review is to current insight advances regarding how gut-derived hormones regulate bone homeostasis in humans, emphasizing gut-bone axis and bone regeneration. The GM may be engaged in bone metabolism and fracture risk. Additional investigations of the fundamental microbiota-related pathways in bone metabolism may uncover treatment strategies and enable the prevention of osteoporosis. A better knowledge of gut hormones' action on bone homeostasis may lead to new strategies for preventing and treating skeletal frailty related to age.
数据收集表明，肠道微生物群（GM）与涉及宿主-微生物群相互作用的骨稳态之间存在复杂的相关性。尽管已知GM会影响骨代谢，但其相关作用机制仍不清楚。本综述的目的是介绍目前关于肠道衍生激素如何调节人体骨稳态的见解进展，重点关注肠-骨轴和骨再生。GM可能参与骨代谢和骨折风险。对骨代谢中与微生物群相关的基本途径进行更多研究，可能会发现治疗策略并预防骨质疏松症。更好地了解肠道激素对骨稳态的作用，可能会带来预防和治疗与年龄相关的骨骼脆弱的新策略。
