Abdel-Massih Roula M, Debs Espérance, Othman Leen, Attieh Jihad, Cabrerizo Franco M
College of Medicine, Central Michigan University, Mount Pleasant, MI, United States.
Department of Biology, Faculty of Arts and Sciences, University of Balamand, El-Koura, Lebanon.
Front Microbiol. 2023 Apr 5;14:1130208. doi: 10.3389/fmicb.2023.1130208. eCollection 2023.
Glucosinolates are a group of thioglucosides that belong to the class of plant nitrogen-containing natural products. So far, very little biological activity has been associated with intact glucosinolates. The hydrolysis of glucosinolates has, for long, attracted attention because of the potent biological activity of the hydrolysis products. From allelopathic to antiparasitic, antimicrobial and antineoplastic effects, the activity spectrum of the degradation products of typical glucosinolates has been the subject of much research. The present review seeks to address the various means of glucosinolate degradation (thermal, enzymatic, or chemical degradation) and the ensuing products. It also aims to draw a comparative profile of the various antimicrobial effects of these degradation products to provide a further understanding of the biological function of these important compounds.
硫代葡萄糖苷是一类硫代糖苷，属于植物含氮天然产物类别。到目前为止，完整的硫代葡萄糖苷几乎没有相关生物活性。长期以来，硫代葡萄糖苷的水解因其水解产物具有强大的生物活性而备受关注。从化感作用到抗寄生虫、抗菌和抗肿瘤作用，典型硫代葡萄糖苷降解产物的活性谱一直是众多研究的主题。本综述旨在探讨硫代葡萄糖苷降解的各种方式（热降解、酶降解或化学降解）及随后产生的产物。它还旨在绘制这些降解产物各种抗菌作用的比较概况，以进一步了解这些重要化合物的生物学功能。
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