Mansfield F, Polivy K, Boyd R, Huddleston J
Clin Orthop Relat Res. 1986 May(206):67-9.
A 10- to 14-year follow-up questionnaire of 146 patients treated for sciatica from a herniated nucleus pulposus by chymopapain (Discase) injection revealed a durable, satisfactory result in 66%. In the 102 patients rated as excellent or good, 5% required surgical discectomy 50-82 months after injection. One-, two-, and three-level injections were performed and the number of levels injected did not influence the success of the procedure or the subsequent need for open surgical intervention. There was no correlation shown between the incidence of job change or unemployment and the number of levels injected.
一份针对146例因髓核突出导致坐骨神经痛而接受木瓜凝乳蛋白酶（Disase）注射治疗的患者的10至14年随访调查问卷显示，66%的患者取得了持久、满意的效果。在被评为优或良的102例患者中，5%在注射后50至82个月需要进行手术椎间盘切除术。进行了单节段、双节段和三节段注射，注射的节段数量并未影响该手术的成功率或随后进行开放性手术干预的必要性。工作变动或失业的发生率与注射的节段数量之间未显示出相关性。
