Xie Long, Zhao Yu-Xin, Zheng Yu, Li Xiao-Fang
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Pharmacol. 2023 Apr 6;14:1148853. doi: 10.3389/fphar.2023.1148853. eCollection 2023.
Chinese doctors widely prescribed A. DC. (PG) to treat lung carbuncles in ancient China. Modern clinical experiences have demonstrated that PG plays a crucial role in treating chronic pharyngitis, plum pneumonia, pneumoconiosis, acute and chronic laryngitis, and so forth. Additionally, PG is a food with a long history in China, Japan, and Korea. Furthermore, Platycodin D (PLD), an oleanane-type triterpenoid saponin, is one of the active substances in PG. PLD has been revealed to have anti-inflammatory, anti-viral, anti-oxidation, anti-obesity, anticoagulant, spermicidal, anti-tumor etc., activities. And the mechanism of the effects draws lots of attention, with various signaling pathways involved in these processes. Additionally, research on PLD's pharmacokinetics and extraction processes is under study. The bioavailability of PLD could be improved by being prescribed with Fisch. or by creating a new dosage form. PLD has been recently considered to have the potential to be a solubilizer or an immunologic adjuvant. Meanwhile, PLD was discovered to have hemolytic activity correlated. PLD has broad application prospects and reveals practical pharmacological activities in pre-clinical research. The authors believe that these activities of PLD contribute to the efficacy of PG. What is apparent is that the clinical translation of PLD still has a long way to go. With the help of modern technology, the scope of clinical applications of PLD is probable to be expanded from traditional applications to new fields.
中国古代医生广泛使用桔梗（PG）治疗肺痈。现代临床经验表明，PG在治疗慢性咽炎、梅核气、尘肺病、急慢性喉炎等方面发挥着关键作用。此外，PG在中国、日本和韩国是一种历史悠久的食物。此外，齐墩果烷型三萜皂苷桔梗皂苷D（PLD）是PG中的活性成分之一。已发现PLD具有抗炎、抗病毒、抗氧化、抗肥胖、抗凝、杀精、抗肿瘤等活性。其作用机制备受关注，这些过程涉及多种信号通路。此外，关于PLD的药代动力学和提取工艺的研究正在进行中。与 Fisch. 联合使用或制成新剂型可提高PLD的生物利用度。最近认为PLD有潜力成为增溶剂或免疫佐剂。同时，发现PLD具有溶血活性。PLD在临床前研究中具有广阔的应用前景并显示出实际的药理活性。作者认为PLD的这些活性有助于PG的疗效。显然，PLD的临床转化仍有很长的路要走。借助现代技术，PLD的临床应用范围可能从传统应用扩展到新领域。
