Wu Hao-Jia, Xiao Zhi-Gang, Lv Xiao-Juan, Huang Hai-Tang, Liao Chu, Hui Chen-Yang, Xu Yue, Li Heng-Fei
Clinical College of Traditional Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, P.R. China.
Department of Orthopedics, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430061, P.R. China.
Exp Ther Med. 2023 Mar 23;25(5):209. doi: 10.3892/etm.2023.11908. eCollection 2023 May.
Bacterial drug resistance is increasingly becoming an important problem that needs to be solved urgently in modern clinical practices. Infection caused by is a serious threat to the life and health of patients. The drug resistance rate of strains is increasing, thus research on the drug resistance of has also seen an increase. When patients are infected with drug-resistant , the availability of suitable antibiotics commonly used in clinical practices is becoming increasingly limited and the prognosis of patients is worsening. Studying the molecular mechanism of the drug resistance of is fundamental to solving the problem of drug-resistant and potentially other 'super bacteria'. Drug resistance mechanisms primarily include enzymes, membrane proteins, efflux pumps and beneficial mutations. Research on the underlying mechanisms provides a theoretical basis for the use and development of antibiotics and the development of novel treatment methods.
细菌耐药性日益成为现代临床实践中亟待解决的重要问题。由[未提及具体细菌名称]引起的感染对患者的生命健康构成严重威胁。[未提及具体细菌名称]菌株的耐药率不断上升，因此对[未提及具体细菌名称]耐药性的研究也日益增多。当患者感染耐药性[未提及具体细菌名称]时，临床常用的合适抗生素的可用性越来越有限，患者的预后也在恶化。研究[未提及具体细菌名称]的耐药分子机制是解决耐药性[未提及具体细菌名称]以及潜在的其他“超级细菌”问题的基础。耐药机制主要包括酶、膜蛋白、外排泵和有益突变。对潜在机制的研究为抗生素的使用和开发以及新治疗方法的开发提供了理论依据。
