Institute of Medical Technology, Brandenburg University of Technology Cottbus-Senftenberg, Cottbus, Germany.
Ergonomics and Innovation, Chemnitz University of Technology, Chemnitz, Germany.
Exp Brain Res. 2023 Jun;241(6):1523-1531. doi: 10.1007/s00221-023-06619-4. Epub 2023 Apr 25.
Motion sickness is a physiological condition that negatively impacts a person's comfort and will be an emerging condition in autonomous vehicles without proper countermeasures. The vestibular system plays a key role in the origin of motion sickness. Understanding the susceptibility and (mal) adaptive mechanisms of the highly integrated vestibular system is a prerequisite for the development of countermeasures. We hypothesize a differential association between motion sickness and vestibular function in healthy individuals with and without susceptibility for motion sickness. We quantified vestibular function by measuring the high-frequency vestibulo-ocular reflex (VOR) using video head impulse testing (vHIT) in 17 healthy volunteers before and after a 11 min motion sickness-inducing naturalistic stop-and-go car ride on a test track (Dekra Test Oval, Klettwitz, Germany). The cohort was classified as motion sickness susceptible (n = 11) and non-susceptible (n = 6). Six (out of 11) susceptible participants developed nausea symptoms, while a total of nine participants were free of these symptoms. The VOR gain (1) did not differ significantly between participant groups with (n = 8) and without motion sickness symptoms (n = 9), (2) did not differ significantly in the factor time before and after the car ride, and showed no interaction between symptom groups and time, as indicated by a repeated measures ANOVA (F(1,15) = 2.19, p = 0.16. Bayesian inference confirmed that there was "anecdotal evidence" for equality of gain rather than difference across groups and time (BF < 0.77). Our results suggest that individual differences in VOR measures or adaptation to motion sickness provocative stimuli during naturalistic stop-and-go driving cannot predict motion sickness susceptibility or the likelihood of developing motion sickness.
晕车是一种会降低人的舒适度的生理状况，如果没有适当的对策，在自动驾驶汽车中，这种状况将会出现。前庭系统在晕车的发生中起着关键作用。了解高度集成的前庭系统的易感性和（不良）适应机制是开发对策的前提。我们假设在有和没有晕车易感性的健康个体中，晕车与前庭功能之间存在差异关联。我们通过视频头脉冲测试（vHIT）在 17 名健康志愿者在德克拉测试椭圆形（Dekra Test Oval，Klettwitz，德国）测试轨道上进行 11 分钟的晕车诱发自然停走汽车行驶前后测量高频前庭眼反射（VOR）来量化前庭功能。该队列被分为晕车易感组（n=11）和非易感组（n=6）。在易感组中，有 6 人（6/11）出现恶心症状，而总共有 9 人没有这些症状。VOR 增益（1）在有（n=8）和没有晕车症状（n=9）的参与者组之间没有显著差异，（2）在乘车前后的时间因素中没有显著差异，并且在症状组和时间之间没有交互作用，这表明重复测量方差分析（F（1，15）=2.19，p=0.16）。贝叶斯推理证实，在组间和时间上，增益的平等存在“传闻证据”而不是差异（BF<0.77）。我们的结果表明，VOR 测量或在自然停走驾驶期间对晕车刺激性刺激的适应的个体差异不能预测晕车易感性或发生晕车的可能性。
