Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Beijing Institute of Heart Lung and Blood Vessel Disease, Clinical Center for Coronary Heart Disease, Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Mil Med Res. 2023 Apr 26;10(1):18. doi: 10.1186/s40779-023-00452-0.
Heart injury such as myocardial infarction leads to cardiomyocyte loss, fibrotic tissue deposition, and scar formation. These changes reduce cardiac contractility, resulting in heart failure, which causes a huge public health burden. Military personnel, compared with civilians, is exposed to more stress, a risk factor for heart diseases, making cardiovascular health management and treatment innovation an important topic for military medicine. So far, medical intervention can slow down cardiovascular disease progression, but not yet induce heart regeneration. In the past decades, studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart injury. Insights have emerged from studies in animal models and early clinical trials. Clinical interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart disease. In this review, we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.
心脏损伤，如心肌梗死，导致心肌细胞丧失、纤维组织沉积和瘢痕形成。这些变化降低了心脏的收缩能力，导致心力衰竭，给公共健康带来了巨大负担。与平民相比，军人面临更多的压力，这是心脏病的一个危险因素，因此，心血管健康管理和治疗创新是军事医学的一个重要课题。到目前为止，医学干预可以减缓心血管疾病的进展，但还不能诱导心脏再生。在过去的几十年中，研究集中在心脏再生能力的机制以及适用的方法来逆转心脏损伤。动物模型和早期临床试验的研究结果已经出现。临床干预显示出减少瘢痕形成和增强心肌细胞增殖的潜力，从而对抗心脏病的发病机制。在这篇综述中，我们讨论了控制心脏组织再生的信号事件，并总结了目前促进损伤后心脏再生的治疗方法。
