South African National Blood Service, Johannesburg, South Africa.
Vitalant Research Institute, San Francisco, California, United States of America.
PLoS One. 2023 Apr 26;18(4):e0284975. doi: 10.1371/journal.pone.0284975. eCollection 2023.
Naturally occurring antibodies against ABO antigens present in human sera have been shown to neutralize ABO-expressing HIV in vitro. We investigated associations between ABO and RhD blood groups and HIV infection among blood donors from all blood collection centers in eight of South Africa's nine provinces. Whole blood donations collected from first time donors between January 2012 and September 2016 were tested for HIV RNA by nucleic acid testing and HIV antibody using third generation serology assays. ABO and RhD blood types were determined using automated technology. Odds ratios for the association between HIV positivity and ABO and RhD phenotypes were calculated using multivariable logistic regression analysis. We analyzed 515,945 first time blood donors and the overall HIV prevalence was 1.12% (n = 5790). After multivariable adjustment, HIV infection was weakly associated with RhD positive phenotype (OR = 1.15, 95% CI 1.00-1.33) but not with ABO blood group. The observed association with RhD positive phenotype was marginal and likely due to residual confounding by racial group but could serve to generate hypotheses for further studies.
已证实，人血清中天然存在的针对 ABO 抗原的抗体能够中和体外表达的 HIV。我们调查了南非九个省份中八个省份所有采血中心的献血者的 ABO 和 RhD 血型与 HIV 感染之间的关联。2012 年 1 月至 2016 年 9 月期间，首次献血的献血者的全血采集物通过核酸检测和第三代血清学检测进行 HIV RNA 和 HIV 抗体检测。使用自动化技术确定 ABO 和 RhD 血型。使用多变量逻辑回归分析计算 HIV 阳性与 ABO 和 RhD 表型之间关联的比值比。我们分析了 515945 名首次献血者，总体 HIV 流行率为 1.12%（n=5790）。经过多变量调整后，HIV 感染与 RhD 阳性表型呈弱相关（OR=1.15，95%CI 1.00-1.33），但与 ABO 血型无关。与 RhD 阳性表型的观察到的关联是边缘的，可能是由于种族群体的残余混杂所致，但可以为进一步研究提供假设。
