Soutar R L, Coghill S B
Gastroenterology. 1986 Jul;91(1):84-93. doi: 10.1016/0016-5085(86)90443-9.
Tripotassium dicitrato bismuthate (TDB), De-Nol, heals peptic ulcers with an efficacy similar to the H2 antagonists. Tripotassium dicitrato bismuthate may also be effective in decreasing relapse rates. Its mode of action is unknown, but it was recently observed that TDB rapidly increased the number of macrophages in experimental ulcers. This might accelerate reparative processes, accounting for the drug's action. Using more sophisticated techniques we could not demonstrate any macrophage influx in response to single, or multiple, doses of TDB. Electron micrographs did demonstrate that monocytes, the precursors of macrophages, could internalize TDB. This process occurred rapidly in the presence of plasma where an avid TDB-protein interaction was observed. It has been suggested that such an interaction upon the ulcer may form a protective layer allowing mucosal regeneration to occur unhindered beneath. We believe our electron micrographs support this theory.
枸橼酸铋钾（TDB，得乐）治疗消化性溃疡的疗效与H2拮抗剂相似。枸橼酸铋钾在降低复发率方面可能也有效。其作用方式尚不清楚，但最近观察到TDB能迅速增加实验性溃疡中巨噬细胞的数量。这可能会加速修复过程，从而解释了该药物的作用。使用更精密的技术，我们未能证明单次或多次给予TDB会有巨噬细胞流入。电子显微镜照片确实显示，巨噬细胞的前体细胞单核细胞能够摄取TDB。在血浆存在的情况下，这个过程迅速发生，且观察到TDB与蛋白质有强烈的相互作用。有人提出，这种在溃疡处的相互作用可能形成一层保护层，使黏膜在其下方不受阻碍地再生。我们认为我们的电子显微镜照片支持这一理论。
