治疗对消化性疾病中幽门螺杆菌的影响：一项随机前瞻性试验。
Effect of treatment on Campylobacter pylori in peptic disease: a randomised prospective trial.
作者信息
Humphreys H, Bourke S, Dooley C, McKenna D, Power B, Keane C T, Sweeney E C, O'Moráin C
机构信息
Department of Clinical Microbiology, St James's Hospital, Dublin, Ireland.
出版信息
Gut. 1988 Mar;29(3):279-83. doi: 10.1136/gut.29.3.279.
Abstract
This study investigated the effect of colloidal bismuth subcitrate and cimetidine on Campylobacter pylori in peptic disease. In 74% of 135 patients with peptic disease diagnosed at endoscopy C pylori was detected before treatment. Compared with cimetidine, colloidal bismuth subcitrate significantly decreased the incidence of C pylori after six weeks of treatment (p less than 0.001). In the colloidal bismuth subcitrate group, subsequent healing of the lesion was correlated with the clearance of C pylori, unlike in the cimetidine group. C pylori was strongly associated with the presence of histological gastritis, which was decreased by colloidal bismuth subcitrate (p less than 0.001).
摘要
本研究调查了枸橼酸铋胶体和西咪替丁对消化性疾病中幽门螺杆菌的影响。在内镜检查确诊的135例消化性疾病患者中，74%在治疗前检测到幽门螺杆菌。与西咪替丁相比，枸橼酸铋胶体在治疗六周后显著降低了幽门螺杆菌的感染率（p<0.001）。在枸橼酸铋胶体组中，病变的后续愈合与幽门螺杆菌的清除相关，而西咪替丁组则不同。幽门螺杆菌与组织学胃炎的存在密切相关，枸橼酸铋胶体可使其减少（p<0.001）。
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