用于灵敏测定多西环素的绿色环保型电化学传感平台。
Green ecofriendly electrochemical sensing platform for the sensitive determination of doxycycline.
作者信息
Asran Aml M, Mohamed Mona A, Abd El-Rahman Mohamed K, Mousavi Maral P S
机构信息
Deanship of the Common First Year, Jouf University, El-Jouf, Saudi Arabia.
Faculty of Engineering, Modern Academy for Technology and Engineering, Cairo, Egypt.
出版信息
Heliyon. 2023 Apr 5;9(4):e15223. doi: 10.1016/j.heliyon.2023.e15223. eCollection 2023 Apr.
The detection of pharmaceutical compounds in extremely low concentrations remains a challenge despite recent advancements in electrochemical sensing. In this study, a green hydrothermally synthesized nickel hydroxide-graphene hybrid material was used for the point-of-care determination of the antibiotic doxycycline (DOXY), which is a promising treatment for COVID-19 and other infections. The electrochemical sensor, based on a screen-printed electrode modified with the hybrid material, was able to detect DOXY in the range of 5.1 × 10 to 1.0 × 10 M, with a low detection limit of 9.6 × 10 M. This approach paves the way for eco-friendly and sustainable methods of nanomaterial synthesis for electrochemical analyses, particularly in point-of-care drug monitoring, and has the potential to improve access to testing platforms.
尽管电化学传感技术最近取得了进展，但检测极低浓度的药物化合物仍然是一项挑战。在本研究中，一种绿色水热合成的氢氧化镍-石墨烯混合材料被用于即时检测抗生素多西环素（DOXY），它是治疗新冠肺炎和其他感染的一种有前景的药物。基于用该混合材料修饰的丝网印刷电极的电化学传感器能够检测浓度范围为5.1×10至1.0×10 M的多西环素，检测限低至9.6×10 M。这种方法为电化学分析的纳米材料合成提供了环保且可持续的方法，特别是在即时护理药物监测方面，并且有可能改善检测平台的可及性。
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