Tian Na, Fa Wenxin, Dong Yi, Liu Rui, Liu Cuicui, Liu Keke, Mao Ming, Zhu Min, Liang Xiaoyan, Wang Nan, Ma Yixun, Ngandu Tiia, Launer Lenore J, Wang Yongxiang, Hou Tingting, Du Yifeng, Qiu Chengxuan
Department of Neurology Shandong Provincial Hospital affiliated to Shandong First Medical University Jinan P.R. China.
Shandong Provincial Clinical Research Center for Neurological Diseases Jinan P.R. China.
Alzheimers Dement (Amst). 2023 Apr 23;15(2):e12426. doi: 10.1002/dad2.12426. eCollection 2023 Apr-Jun.
Population-based studies have rarely explored the associations of the triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, with dementia and plasma biomarkers for amyloid beta (Aβ) and neurodegeneration.
This population-based study included 5199 participants (age ≥ 65 years); of these, plasma Aβ, total tau, and neurofilament light chain (NfL) were measured in 1287 persons. Dementia and subtypes were diagnosed following the international criteria. TyG index was calculated as ln(fasting triglyceride(mg/dL) × fasting glucose[mg/dL]/2). Data were analyzed using logistic and general linear regression models.
Dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were diagnosed in 301, 195, and 95 individuals, respectively. A high TyG index was significantly associated with increased likelihoods of dementia and AD; the significant association with dementia remained among participants without cardiovascular disease or diabetes. In the biomarker subsample, a high TyG index was correlated with elevated plasma Aβ, but not with total tau or NfL.
High TyG index is associated with dementia, possibly via Aβ pathology.
基于人群的研究很少探讨甘油三酯-葡萄糖（TyG）指数（一种胰岛素抵抗的替代标志物）与痴呆症以及淀粉样β蛋白（Aβ）和神经退行性变的血浆生物标志物之间的关联。
这项基于人群的研究纳入了5199名参与者（年龄≥65岁）；其中，对1287人测量了血浆Aβ、总tau蛋白和神经丝轻链（NfL）。根据国际标准诊断痴呆症及其亚型。TyG指数的计算方法为ln（空腹甘油三酯[mg/dL]×空腹血糖[mg/dL]/2）。使用逻辑回归和一般线性回归模型分析数据。
分别有301、195和95人被诊断为痴呆症、阿尔茨海默病（AD）和血管性痴呆（VaD）。高TyG指数与痴呆症和AD的患病可能性增加显著相关；在没有心血管疾病或糖尿病的参与者中，与痴呆症的显著关联依然存在。在生物标志物子样本中，高TyG指数与血浆Aβ升高相关，但与总tau蛋白或NfL无关。
高TyG指数与痴呆症相关，可能是通过Aβ病理机制。
