Righi Cecilia, Franzoni Giulia, Feliziani Francesco, Jones Clinton, Petrini Stefano
National Reference Centre for Infectious Bovine Rhinotracheitis (IBR), Istituto Zooprofilattico Sperimentale Umbria-Marche "Togo Rosati", 06126 Perugia, Italy.
Istituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy.
Vaccines (Basel). 2023 Apr 2;11(4):785. doi: 10.3390/vaccines11040785.
(BoHV-1) is one of the major respiratory pathogens in cattle worldwide. Infection often leads to a compromised host immune response that contributes to the development of the polymicrobial disease known as "bovine respiratory disease". After an initial transient phase of immunosuppression, cattle recover from the disease. This is due to the development of both innate and adaptive immune responses. With respect to adaptive immunity, both humoral and cell-mediated immunity are required to control infection. Thus, several BoHV-1 vaccines are designed to trigger both branches of the adaptive immune system. In this review, we summarize the current knowledge on cell-mediated immune responses directed against BoHV-1 infection and vaccination.
牛疱疹病毒1型（BoHV-1）是全球范围内牛的主要呼吸道病原体之一。感染通常会导致宿主免疫反应受损，进而促使被称为“牛呼吸道疾病”的多微生物疾病的发展。在经历最初的短暂免疫抑制期后，牛会从疾病中恢复。这归因于先天性和适应性免疫反应的发展。就适应性免疫而言，控制感染需要体液免疫和细胞介导免疫。因此，几种BoHV-1疫苗旨在激发适应性免疫系统的两个分支。在本综述中，我们总结了目前关于针对BoHV-1感染和疫苗接种的细胞介导免疫反应的知识。
