Charité - Universitätsmedizin Berlin, Institute of Allergology, Berlin, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Germany.
Skin Res Technol. 2023 Apr;29(4):e13307. doi: 10.1111/srt.13307.
Instrumentation technology for transepidermal water loss measurements has not been substantially modified since its introduction by Nilsson in 1977. Recent progress in sensor development allowed a new sensor arrangement using a matrix of 30 sensors. Raw measurement values are processed with spatial statistical analysis. We aimed to compare the new, multi-sensor probe (Tewameter TM Hex) with the established Tewameter TM 300 probe and to gain reference data for the new parameters of transepidermal energy loss and water vapor concentration on skin.
Baseline measurements and repeated measurements on the volar forearm and assessment on eight different anatomical locations were performed on 24 healthy volunteers (both gender) with the TM Hex and the TM 300.
A significant correlation (p < 0.001; R-coefficient = 0.9) between TM Hex and the TM 300 with a low coefficient of variance (CV) 11% for TM Hex and 19% for TM 300, could be assessed. The CV ranged between 7% (right inner upper arm) and 14% (palms). Average transepidermal heat loss ranged from 12 W/m on the lower leg to 38.8 W/m on the palm.
The correlation between TM Hex and TM 300 along with the robustness of the measurements with the TM Hex shows that the new probe for assessment of epidermal barrier function is comparable to the TM 300. In most conditions, TM Hex provides more accurate measurements than TM 300. New parameters open the field to studying skin's water and energy balance.
自 1977 年 Nilsson 引入以来，用于经皮水分流失测量的仪器技术并未有实质性的改进。最近传感器技术的发展使得使用 30 个传感器矩阵的新传感器布置成为可能。原始测量值经过空间统计分析进行处理。我们旨在比较新的多传感器探头（Tewameter TM Hex）与已建立的 Tewameter TM 300 探头，并获得经皮能量损失和皮肤水蒸气浓度的新参数的参考数据。
在 24 名健康志愿者（男女皆有）的屈侧前臂上进行基线测量和重复测量，并在八个不同解剖位置上进行评估，使用 TM Hex 和 TM 300 进行。
可以评估 TM Hex 和 TM 300 之间存在显著相关性（p < 0.001；R 系数= 0.9），TM Hex 的变异系数（CV）较低，为 11%，TM 300 的 CV 为 19%。CV 范围在 7%（右内上臂）至 14%（手掌）之间。平均经皮热损失范围从小腿的 12 W/m 到手掌的 38.8 W/m。
TM Hex 和 TM 300 之间的相关性以及 TM Hex 测量的稳健性表明，用于评估表皮屏障功能的新型探头与 TM 300 相当。在大多数情况下，TM Hex 提供比 TM 300 更准确的测量。新参数为研究皮肤的水和能量平衡开辟了新的领域。
