Kikuchi K, Asano M, Tagami H, Kato M, Aiba S
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Tohoku University, Sendai, Japan.
Skin Res Technol. 2017 Nov;23(4):597-601. doi: 10.1111/srt.12377. Epub 2017 May 18.
BACKGROUND/PURPOSE: Although measuring transepidermal water loss (TEWL) is important to assess the barrier function of the stratum corneum (SC), the commercially available instruments are rather expensive. Recently launched Model H4500 employs a closed-chamber system to measure TEWL and is more reasonably priced compared to devices currently in general use.
To check the reproducibility of the obtained data with H4500, we conducted measurements on the volar forearms of healthy volunteers and compared these data with those measured with Vapometer and Tewameter . Then, we checked the correlations between the TEWL data obtained with these different devices on the same volar forearms of 15 healthy volunteers before and after the artificial production of barrier damage of the SC by tape stripping or by 0.5% aqueous solution of sodium lauryl sulfate.
The obtained intra-class correlation coefficient (ICC, [1, 1]) with 95% CI of H4500 was 0.927 (0.835-0.978). Namely, an excellent correlation could be found in the values of TEWL measured with these three different instruments not only on healthy skin but also on the artificially barrier-damaged skin.
H4500 is considered to be practical for daily use because of its performance as well as its reasonable price as compared with conventional devices.
背景/目的：尽管测量经表皮水分流失（TEWL）对于评估角质层（SC）的屏障功能很重要，但市面上现有的仪器相当昂贵。最近推出的H4500型号采用密闭腔室系统来测量TEWL，与目前普遍使用的设备相比，价格更为合理。
为了检验使用H4500获得的数据的可重复性，我们对健康志愿者的前臂掌侧进行了测量，并将这些数据与使用Vapometer和Tewameter测量的数据进行比较。然后，我们检查了在15名健康志愿者的同一前臂掌侧，通过胶带剥离或0.5%十二烷基硫酸钠水溶液人为造成SC屏障损伤前后，使用这些不同设备获得的TEWL数据之间的相关性。
H4500获得的组内相关系数（ICC，[1, 1]）及其95%置信区间为0.927（0.835 - 0.978）。也就是说，不仅在健康皮肤上，而且在人为造成屏障损伤的皮肤上，用这三种不同仪器测量的TEWL值之间都能发现极好的相关性。
与传统设备相比，H4500因其性能以及合理的价格，被认为在日常使用中是实用的。
