Heller G V, Treves S T, Parker J A, Duke L A, O'Brien G M, Davis R T, Fitzgibbon C, Packard A B
J Am Coll Cardiol. 1986 Jun;7(6):1295-302. doi: 10.1016/s0735-1097(86)80149-8.
Ultrashort-lived iridium-191m (Ir-191m, physical half-life = 5.0 seconds) has been used in angiocardiography, primarily in pediatric patients. A theoretical obstacle to more widespread use of Ir-191m is the belief that its physical half-life is too short to permit evaluation of left ventricular function in adult patients. To evaluate its usefulness in adults, first pass ejection fractions of the left and right ventricles determined with use of Ir-191m and technetium-99m (Tc-99m) were compared in 33 adult patients. An osmium-191m----iridium-191m (Os-191----Ir-191m) generator was employed to deliver doses of 150 to 250 mCi (5.5 to 9.2 GBq) of Ir-191m for intravenous injection. The whole body radiation absorbed dose with Ir-191m was 15 to 25 mrad. High quality angiocardiograms were obtained with both Tc-99m and Ir-191m. Total counts per image for the right ventricle were 51,000 +/- 8,000 (mean +/- SD) for Ir-191m and 30,000 +/- 8,000 for Tc-99m. The left ventricular counts were comparable for both radiotracers (25,000 +/- 7,000 for Ir-191m and 25,000 +/- 8,000 for Tc-99m). Right ventricular ejection fractions were similar: 44 +/- 8% for Ir-191m and 47 +/- 9% for Tc-99m. The correlation coefficient was 0.93 with a standard deviation of the regression of 3.1% ejection fraction units. The left ventricular ejection fractions were also similar: 45 +/- 14% for Ir-191m and 46 +/- 13% for Tc-99m. The left ventricular ejection fraction correlation coefficient was 0.96 with a standard deviation of the regression of 3.7%.(ABSTRACT TRUNCATED AT 250 WORDS)
超短寿命的铱 - 191m（Ir - 191m，物理半衰期 = 5.0秒）已用于心血管造影，主要用于儿科患者。Ir - 191m更广泛应用的一个理论障碍是人们认为其物理半衰期太短，无法评估成年患者的左心室功能。为了评估其在成人中的实用性，对33例成年患者使用Ir - 191m和锝 - 99m（Tc - 99m）测定的左右心室首次通过射血分数进行了比较。采用锇 - 191m - - - 铱 - 191m（Os - 191 - - - Ir - 191m）发生器提供150至250毫居里（5.5至9.2吉贝可）的Ir - 191m剂量用于静脉注射。Ir - 191m的全身辐射吸收剂量为15至25毫拉德。使用Tc - 99m和Ir - 191m均获得了高质量的心血管造影图像。Ir - 191m的右心室每幅图像的总计数为51,000±8,000（平均值±标准差），Tc - 99m为30,000±8,000。两种放射性示踪剂的左心室计数相当（Ir - 191m为25,000±7,000，Tc - 99m为25,000±8,000）。右心室射血分数相似：Ir - 191m为44±8%，Tc - 99m为47±9%。相关系数为0.93，回归标准差为3.1%射血分数单位。左心室射血分数也相似：Ir - 191m为45±14%，Tc - 99m为46±13%。左心室射血分数相关系数为0.96，回归标准差为3.7%。（摘要截断于250字）
