Schwarz M, Susswein A J
J Neurosci. 1986 May;6(5):1528-36. doi: 10.1523/JNEUROSCI.06-05-01528.1986.
Bilateral sectioning of the esophageal nerves that innervate the gut of Aplysia was found to have profound effect on response decrement to inedible food: Time to criterion for cessation of feeding was elevated, no memory of the decrement was present 24 hr after training, and motor patterning during training was altered. The parametric features of response decrement to sustained lip stimulation were examined to determine their resemblance to parameters of response decrement to inedible food after esophageal nerve sectioning. Parameters of response decrement were similar, indicating that after esophageal nerve sectioning response decrement is likely to be the result of sustained lip stimulation. Bilateral nerve sectioning had no effect on decrement due to sustained lip stimulation. Unilateral lesions and lesions of either of the two major divisions of the esophageal nerves had no effect on learning that food was inedible. The data indicate that bilateral nerve sectioning eliminates all stimuli causing negative reinforcement of feeding due to failure to consume food. Based on the data in this and the previous paper, a model is presented suggesting sites of action and mechanisms for learning that foods are edible or inedible in Aplysia.
对支配海兔肠道的食管神经进行双侧切断，发现对不可食用食物的反应递减有深远影响：达到停止进食标准的时间延长，训练24小时后不存在对递减的记忆，且训练期间的运动模式发生改变。研究了对持续唇部刺激的反应递减的参数特征，以确定它们与食管神经切断后对不可食用食物的反应递减参数的相似性。反应递减的参数相似，表明食管神经切断后反应递减可能是持续唇部刺激的结果。双侧神经切断对因持续唇部刺激导致的递减没有影响。单侧损伤以及食管神经两个主要分支中任何一个的损伤对了解食物不可食用没有影响。数据表明，双侧神经切断消除了由于未能消耗食物而导致对进食产生负强化的所有刺激。基于本文和前一篇论文中的数据，提出了一个模型，表明海兔学习食物可食用或不可食用的作用位点和机制。
