Formulation Laboratory, Dietetics and Nutrition Technology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176061, Himachal Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Formulation Laboratory, Dietetics and Nutrition Technology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176061, Himachal Pradesh, India.
Drug Discov Today. 2023 Jun;28(6):103602. doi: 10.1016/j.drudis.2023.103602. Epub 2023 Apr 28.
Covalent organic frameworks (COFs) have gained tremendous interest in cancer therapy owing to their multifunctional properties, such as biocompatibility, tunable cavities, excellent crystallinity, ease of modification/functionalization, and high flexibility. These unique properties offer multiple benefits, such as high loading capacity, prevention from premature leakage, targeted delivery to the tumor microenvironment (TME), and release of therapeutic agents in a controlled manner, which makes them effective and excellent nanoplatforms for cancer therapeutics. In this review, we outline recent advances in using COFs as delivery system for chemotherapeutic agents, photodynamic therapy (PDT), photothermal therapy (PTT), sonodynamic therapy (SDT), cancer diagnostics, and combinatorial therapy for cancer therapeutics. We also summarize current challenges and future directions of this unique research field.
共价有机框架（COFs）由于其多功能特性，如生物相容性、可调节的孔道、出色的结晶度、易于修饰/功能化以及高灵活性，在癌症治疗领域引起了极大的关注。这些独特的性质提供了多种好处，例如高载药量、防止过早泄漏、靶向递送至肿瘤微环境（TME）以及以可控方式释放治疗剂，这使得它们成为癌症治疗的有效和优秀的纳米平台。在这篇综述中，我们概述了最近将 COFs 用作化疗药物、光动力疗法（PDT）、光热疗法（PTT）、声动力疗法（SDT）、癌症诊断以及癌症治疗的联合疗法的递药系统的进展。我们还总结了这一独特研究领域的当前挑战和未来方向。
