Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China.
J Mater Chem B. 2021 Apr 28;9(16):3450-3483. doi: 10.1039/d1tb00041a.
Cancer nanomedicine is the best option to face the limits of conventional chemotherapy and phototherapy methods, and thus the intensive quest for new nanomaterials to improve therapeutic efficacy and safety is still underway. Owing to their low density, well-defined structures, large surface area, finely tunable pore size, and metal ion free features, covalent organic frameworks (COFs) have been extensively studied in many research fields. The recent great interest in nanoscale COFs to improve the properties of bulk COFs has led to broadening of their applicability in the biomedical field, such as nanocarriers with an outstanding loading capacity and efficient delivery of therapeutic agents, smart theranostic nanoplatforms with excellent stability, high ROS generation, light-to-heat conversion capabilities, and different response and diagnostic characteristics. The COFs and related nanoplatforms with a wide variety of designability and functionalization have opened up a new avenue for exciting opportunities in cancer therapy. Herein we review the state-of-the-art technical and scientific developments in this emerging field, focusing on the overall progress addressed so far in building versatile COF-based nanoplatforms to enhance chemotherapy, photodynamic/photothermal therapy, and combination. Future perspectives for achieving the synergistic effect of cancer elimination and clinical translation are further discussed to motivate future contributions and explore new possibilities.
癌症纳米医学是应对传统化疗和光疗方法局限性的最佳选择，因此，人们仍在积极寻求新的纳米材料以提高治疗效果和安全性。由于其低密度、结构明确、比表面积大、孔径可精细调节以及不含金属离子等特点，共价有机骨架（COFs）在许多研究领域得到了广泛研究。最近，人们对纳米尺度 COFs 改善块状 COFs 性能的极大兴趣，使得 COFs 在生物医学领域的应用得到了拓宽，例如具有出色载药能力和高效递药性能的纳米载体、具有优异稳定性、高效生成 ROS、光热转换能力以及不同响应和诊断特性的智能诊疗纳米平台。具有多种设计性和功能化的 COFs 和相关纳米平台为癌症治疗带来了令人兴奋的新机遇。本文综述了该新兴领域的最新技术和科学进展，重点介绍了迄今为止在构建多功能 COF 基纳米平台以增强化学疗法、光动力/光热疗法以及联合治疗方面的整体进展。进一步讨论了实现癌症消除和临床转化协同效应的未来展望，以激励未来的贡献并探索新的可能性。
