• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

动作电位之外的电压门控钾通道

Voltage-Gated Potassium Channels Beyond the Action Potential.

作者信息

Pardo Luis A

机构信息

Oncophysiology Group, Max Planck Institute for Multidisciplinary Sciences (MPI-NAT), Göttingen, Germany.

出版信息

Bioelectricity. 2022 Jun 1;4(2):117-125. doi: 10.1089/bioe.2022.0014. Epub 2022 May 26.

DOI:10.1089/bioe.2022.0014
PMID:37124580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10133977/
Abstract

Bioelectricity goes far beyond electrical signaling in the nervous system, but this was initially not obvious for me. This article describes the journey from studying the biophysics of ion channels in classical electrically excitable tissues to focusing on the pathogenic roles of the Kv10.1 potassium channel in cancers.

摘要

生物电远不止于神经系统中的电信号传导，但这一点最初我并不清楚。本文描述了从研究经典电兴奋性组织中离子通道的生物物理学到关注Kv10.1钾通道在癌症中的致病作用的历程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf5/10133977/b6f57cb93081/bioe.2022.0014_figure6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf5/10133977/6187f2d1ee31/bioe.2022.0014_figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf5/10133977/66206997bd51/bioe.2022.0014_figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf5/10133977/36527cffc897/bioe.2022.0014_figure3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf5/10133977/32cffdc8c0db/bioe.2022.0014_figure4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf5/10133977/7f91589c4e3d/bioe.2022.0014_figure5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf5/10133977/b6f57cb93081/bioe.2022.0014_figure6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf5/10133977/6187f2d1ee31/bioe.2022.0014_figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf5/10133977/66206997bd51/bioe.2022.0014_figure2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf5/10133977/36527cffc897/bioe.2022.0014_figure3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf5/10133977/32cffdc8c0db/bioe.2022.0014_figure4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf5/10133977/7f91589c4e3d/bioe.2022.0014_figure5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbf5/10133977/b6f57cb93081/bioe.2022.0014_figure6.jpg

相似文献

1
Voltage-Gated Potassium Channels Beyond the Action Potential.动作电位之外的电压门控钾通道
Bioelectricity. 2022 Jun 1;4(2):117-125. doi: 10.1089/bioe.2022.0014. Epub 2022 May 26.
2
Kv10.1 potassium channel: from the brain to the tumors.Kv10.1钾通道：从大脑到肿瘤
Biochem Cell Biol. 2017 Oct;95(5):531-536. doi: 10.1139/bcb-2017-0062. Epub 2017 Jul 14.
3
PIST (GOPC) modulates the oncogenic voltage-gated potassium channel KV10.1.PIST（GOPC）调节致癌性电压门控钾通道 KV10.1。
Front Physiol. 2013 Aug 14;4:201. doi: 10.3389/fphys.2013.00201. eCollection 2013.
4
Differential effect of brief electrical stimulation on voltage-gated potassium channels.短暂电刺激对电压门控钾通道的差异效应。
J Neurophysiol. 2017 May 1;117(5):2014-2024. doi: 10.1152/jn.00915.2016. Epub 2017 Feb 15.
5
Thallium-sensitive fluorescent assay reveals loperamide as a new inhibitor of the potassium channel Kv10.1.铊敏感荧光分析法揭示洛哌丁胺是钾通道 Kv10.1 的一种新抑制剂。
Pharmacol Rep. 2021 Dec;73(6):1744-1753. doi: 10.1007/s43440-021-00304-5. Epub 2021 Jul 2.
6
Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels.用于探测电压门控离子通道功能和药理学的光学电生理学
Elife. 2016 May 24;5:e15202. doi: 10.7554/eLife.15202.
7
Alternatively Spliced Isoforms of KV10.1 Potassium Channels Modulate Channel Properties and Can Activate Cyclin-dependent Kinase in Xenopus Oocytes.钾通道 KV10.1 的可变剪接异构体调节通道特性并能在非洲爪蟾卵母细胞中激活细胞周期蛋白依赖性激酶。
J Biol Chem. 2015 Dec 18;290(51):30351-65. doi: 10.1074/jbc.M115.668749. Epub 2015 Oct 30.
8
APETx4, a Novel Sea Anemone Toxin and a Modulator of the Cancer-Relevant Potassium Channel K10.1.APETx4，一种新型海葵毒素，也是一种癌症相关钾通道 K10.1 的调节剂。
Mar Drugs. 2017 Sep 13;15(9):287. doi: 10.3390/md15090287.
9
A subfraction obtained from the venom of the tarantula contains inhibitor cystine knot peptides and induces relaxation of rat aorta by inhibiting L-type voltage-gated calcium channels.从狼蛛毒液中获得的一个亚组分含有抑制性胱氨酸结肽，并通过抑制L型电压门控钙通道诱导大鼠主动脉舒张。
Toxicon X. 2023 Feb 17;18:100151. doi: 10.1016/j.toxcx.2023.100151. eCollection 2023 Jun.
10
The Kv10.1 Channel: A Promising Target in Cancer.Kv10.1 通道：癌症治疗的有前景靶点
Int J Mol Sci. 2022 Jul 30;23(15):8458. doi: 10.3390/ijms23158458.

引用本文的文献

1
Cell Settling, Migration, and Stochastic Cancer Gene Expression Suggest Potassium Membrane Flux May Initiate pH Reversal.细胞沉降、迁移和随机癌症基因表达表明钾离子膜通量可能引发pH值逆转。
Biomolecules. 2025 Aug 16;15(8):1177. doi: 10.3390/biom15081177.
2
The Role of the Swollen State in Cell Proliferation.肿胀状态在细胞增殖中的作用。
J Membr Biol. 2025 Feb;258(1):1-13. doi: 10.1007/s00232-024-00328-x. Epub 2024 Oct 31.
3
Phytochemical Modulation of Ion Channels in Oncologic Symptomatology and Treatment.肿瘤症状学与治疗中离子通道的植物化学调控

本文引用的文献

1
Molecular Dynamics-Derived Pharmacophore Model Explaining the Nonselective Aspect of K10.1 Pore Blockers.基于分子动力学的配体药效团模型解释 K10.1 孔阻滞剂的非选择性。
Int J Mol Sci. 2021 Aug 20;22(16):8999. doi: 10.3390/ijms22168999.
2
Overcoming challenges of HERG potassium channel liability through rational design: Eag1 inhibitors for cancer treatment.通过合理设计克服 HERG 钾通道毒性的挑战：用于癌症治疗的 Eag1 抑制剂。
Med Res Rev. 2022 Jan;42(1):183-226. doi: 10.1002/med.21808. Epub 2021 May 4.
3
Circ_0016347 Promotes Osteosarcoma Progression by Regulating miR-1225-3p/KCNH1 Axis.
Cancers (Basel). 2024 May 6;16(9):1786. doi: 10.3390/cancers16091786.
4
Bioelectricity in dental medicine: a narrative review.牙科医学中的生物电流：一篇叙述性综述。
Biomed Eng Online. 2024 Jan 3;23(1):3. doi: 10.1186/s12938-023-01189-6.
5
Ion Channels and Personalized Medicine in Gynecological Cancers.妇科癌症中的离子通道与个性化医疗
Pharmaceuticals (Basel). 2023 May 29;16(6):800. doi: 10.3390/ph16060800.
环状 RNA 0016347 通过调控 miR-1225-3p/KCNH1 轴促进骨肉瘤进展。
Cancer Biother Radiopharm. 2023 Nov;38(9):619-631. doi: 10.1089/cbr.2019.3349. Epub 2021 Mar 24.
4
Kv10.1 Regulates Microtubule Dynamics during Mitosis.Kv10.1在有丝分裂过程中调节微管动力学。
Cancers (Basel). 2020 Aug 25;12(9):2409. doi: 10.3390/cancers12092409.
5
A Novel Anti-Kv10.1 Nanobody Fused to Single-Chain TRAIL Enhances Apoptosis Induction in Cancer Cells.一种与单链TRAIL融合的新型抗Kv10.1纳米抗体增强癌细胞凋亡诱导作用。
Front Pharmacol. 2020 May 14;11:686. doi: 10.3389/fphar.2020.00686. eCollection 2020.
6
Inhibition of Kv10.1 Channels Sensitizes Mitochondria of Cancer Cells to Antimetabolic Agents.抑制Kv10.1通道可使癌细胞线粒体对抗代谢药物敏感。
Cancers (Basel). 2020 Apr 9;12(4):920. doi: 10.3390/cancers12040920.
7
Regulation of Eag1 gating by its intracellular domains.Eag1 门控的细胞内结构域调节。
Elife. 2019 Sep 6;8:e49188. doi: 10.7554/eLife.49188.
8
Importance of TRAIL Molecular Anatomy in Receptor Oligomerization and Signaling. Implications for Cancer Therapy.TRAIL分子结构在受体寡聚化和信号传导中的重要性。对癌症治疗的启示。
Cancers (Basel). 2019 Mar 29;11(4):444. doi: 10.3390/cancers11040444.
9
Destabilization of DNA G-Quadruplexes by Chemical Environment Changes during Tumor Progression Facilitates Transcription.肿瘤进展过程中化学环境改变导致 DNA G-四链体结构不稳定，从而促进转录。
J Am Chem Soc. 2018 Jan 17;140(2):642-651. doi: 10.1021/jacs.7b09449. Epub 2018 Jan 8.
10
Gating mechanism of Kv11.1 (hERG) K channels without covalent connection between voltage sensor and pore domains.Kv11.1（hERG）K 通道的门控机制，其电压传感器和孔域之间没有共价连接。
Pflugers Arch. 2018 Mar;470(3):517-536. doi: 10.1007/s00424-017-2093-9. Epub 2017 Dec 21.