Talan M I, Ingram D K
Mech Ageing Dev. 1986 Feb;33(3):247-56. doi: 10.1016/0047-6374(86)90050-3.
The age-related declines in colonic temperature (Tco) and cold tolerance (ability to maintain Tco when exposed to 10 degrees C for 3 h) described for C57BL/6J mice are compared to other mouse strains. Assessment of young and aged male mice of the C57BL/6J and A/J inbred strains and their F1 hybrid, B6AF1/J, as well as a pen-bred strain of Mus musculus captured from the wild revealed an aged-related decline in thermoregulation among all these strains. The degree of decline in thermoregulation was roughly correlated to differences in strain-specific lifespan. Aged mice of the relatively short-lived genotype, A/J (mean lifespan of 22 months), had the lowest Tco and poorest cold tolerance. The long-lived hybrids, B6AF1/J (mean lifespan of 29 months), demonstrated the highest Tco and the best cold tolerance among aged mice. C57BL/6J (mean lifespan of 26 months) showed an intermediate level of thermoregulation. Aged pen-bred mice demonstrated a significant decline in cold tolerance, but not a significant decline in Tco. The thermoregulatory responses of the pen-bred mice were superior to those observed among the domesticated strains. These data suggest that the age-related impairment in thermoregulation is a general phenomenon of aging in Mus musculus that is correlated with strain-specific lifespan but is possibly affected by the level of hybridization and domestication.
将C57BL/6J小鼠出现的与年龄相关的结肠温度（Tco）下降和耐寒性（暴露于10摄氏度3小时时维持Tco的能力）与其他小鼠品系进行比较。对C57BL/6J和A/J近交系的年轻和老年雄性小鼠及其F1杂种B6AF1/J，以及从野外捕获的小家鼠的圈养品系进行评估，结果显示所有这些品系中均存在与年龄相关的体温调节能力下降。体温调节能力下降的程度与品系特异性寿命的差异大致相关。相对短命基因型A/J（平均寿命22个月）的老年小鼠Tco最低，耐寒性最差。长寿杂种B6AF1/J（平均寿命29个月）在老年小鼠中表现出最高的Tco和最佳的耐寒性。C57BL/6J（平均寿命26个月）表现出中等水平的体温调节能力。圈养繁殖的老年小鼠耐寒性显著下降，但Tco没有显著下降。圈养繁殖小鼠的体温调节反应优于在驯化品系中观察到的反应。这些数据表明，与年龄相关的体温调节损伤是小家鼠衰老的普遍现象，与品系特异性寿命相关，但可能受杂交和驯化水平的影响。
