Shefer V I, Talan M I
Laboratory of Behavioral Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA.
Exp Gerontol. 1997 Nov-Dec;32(6):695-705. doi: 10.1016/s0531-5565(97)00085-5.
We studied the effect of exercise training in cold environment (six weeks of daily, one-hour runs on a treadmill at ambient temperature of 6 +/- 1 degrees C at 60-65% of VO2max) on cold-induced metabolic heat production, heat loss, and cold tolerance in adult and aged C57BL/6J male mice. In adult mice, exercise training in cold environment resulted in greater cold-induced heat production and cold tolerance without changes in heat loss, similar to the effects of daily cold exposure without exercise. In aged mice, daily cold exposures did not affect cold tolerance and cold-induced heat production, but exercise training in the cold resulted in greater cold-induced heat production and cold tolerance. Heat loss in aged mice increased similarly after both repeated cold exposures and exercise training in the cold. Therefore, mechanisms of effect of exercise training on cold tolerance are different in adult and aged animals. Exercise training in cold environment does not affect cold-induced heat production and cold tolerance in adult mice, but improves them in aged animals.
我们研究了在寒冷环境中进行运动训练（每天在跑步机上跑步一小时，持续六周，环境温度为6±1摄氏度，运动强度为最大摄氧量的60-65%）对成年和老年C57BL/6J雄性小鼠冷诱导代谢产热、热量散失和耐寒性的影响。在成年小鼠中，寒冷环境下的运动训练导致冷诱导产热增加和耐寒性增强，而热量散失没有变化，这与每天不运动的冷暴露效果相似。在老年小鼠中，每天的冷暴露不影响耐寒性和冷诱导产热，但在寒冷环境中的运动训练导致冷诱导产热增加和耐寒性增强。在老年小鼠中，重复冷暴露和寒冷环境中的运动训练后，热量散失的增加情况相似。因此，运动训练对耐寒性的影响机制在成年和老年动物中有所不同。寒冷环境中的运动训练不影响成年小鼠的冷诱导产热和耐寒性，但能改善老年动物的这些指标。
