Hopkins A L, Yeung H N, Bratton C B
Magn Reson Med. 1986 Apr;3(2):303-11. doi: 10.1002/mrm.1910030214.
To estimate the feasibility of measuring in vivo CSF protein, oxygen, or other solutes through their effect on proton relaxation times, the T1 and T2 of CSF protons has been measured within the human lateral ventricles. T1 was measured at 6.25, 25.4, and 60.1 MHz with a two-point method. T2 was measured at 6.25 and 25.4 MHz using the CPMG sequence to acquire 8 echo images. The T1 was 4.3 s with no evidence of field dependence. The T2 was 2 s. Although these values approach those for water at the same temperature it is possible that the T1 is influenced by the normal oxygen concentration. Calculations based on the relaxivity of dissolved protein indicate that the use of these methods for the detection of elevated levels of CSF protein would be less sensitive than existing methods.
为了评估通过质子弛豫时间的变化来测量体内脑脊液蛋白质、氧气或其他溶质的可行性，我们在人体侧脑室内测量了脑脊液质子的T1和T2。采用两点法在6.25、25.4和60.1 MHz频率下测量T1。使用CPMG序列在6.25和25.4 MHz频率下测量T2，采集8幅回波图像。T1为4.3秒，没有场依赖性的证据。T2为2秒。尽管这些值接近相同温度下水的值，但T1可能受到正常氧浓度的影响。基于溶解蛋白质弛豫率的计算表明，使用这些方法检测脑脊液蛋白质水平升高的灵敏度低于现有方法。
