Department of Clinical Immunology and Rheumatology, Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, India.
Department of Pharmacotherapy, College of Pharmacy, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Int J Rheum Dis. 2023 Jun;26(6):1111-1119. doi: 10.1111/1756-185X.14710. Epub 2023 May 3.
Restless leg syndrome (RLS) is a neurological disorder characterized by an uncontrollable desire to move legs along with abnormal sensations, particularly at night, which can lead to sleep disturbance. RLS may mimic rheumatic diseases or can be associated with them, hence their identification and treatment are important to improve sleep quality and overall quality of life in rheumatic diseases.
We conducted a search of the PubMed, SCOPUS, and EMBASE databases to identify studies reporting a prevalence of RLS in patients with rheumatic disease. Two authors independently screened, selected, and extracted the data. Heterogeneity was assessed using I statistics and random effect method of the meta-analysis was used to synthesize the results.
Out of 273 unique records, 17 eligible studies including 2406 rheumatic patients were identified. RLS prevalence (95% CI) among patients of rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, fibromyalgia and ankylosing spondylitis are found to be 26.6% (18.6 34.6); 32.5% (23.1-41.9), 4.4% (2.0-6.8), 38.1% (31.3-45.0) and 30.8% (23.48-39.16) respectively. RLS prevalence was similar for males and females.
Our study indicates a high prevalence of RLS in patients with rheumatic diseases. Early detection and treatment of RLS in patients with rheumatic conditions could be beneficial in improving their overall health and quality of life.
不宁腿综合征（RLS）是一种神经系统疾病，其特征是腿部无法控制地移动，并伴有异常感觉，尤其是在夜间，这会导致睡眠障碍。RLS 可能模仿风湿性疾病，也可能与之相关，因此识别和治疗 RLS 对于改善风湿性疾病患者的睡眠质量和整体生活质量非常重要。
我们检索了 PubMed、SCOPUS 和 EMBASE 数据库，以确定报告风湿性疾病患者 RLS 患病率的研究。两名作者独立筛选、选择和提取数据。使用 I 统计量评估异质性，并使用荟萃分析的随机效应方法来综合结果。
在 273 条独特记录中，确定了 17 项符合条件的研究，其中包括 2406 名风湿性疾病患者。类风湿关节炎、系统性红斑狼疮、骨关节炎、纤维肌痛和强直性脊柱炎患者的 RLS 患病率（95%CI）分别为 26.6%（18.6-34.6）、32.5%（23.1-41.9）、4.4%（2.0-6.8）、38.1%（31.3-45.0）和 30.8%（23.48-39.16）。男女 RLS 患病率相似。
我们的研究表明，风湿性疾病患者的 RLS 患病率较高。在风湿性疾病患者中早期发现和治疗 RLS 可能有益于改善其整体健康和生活质量。
