Brown B, Adams A J, Coletta N J, Haegerstrom-Portnoy G
Ophthalmic Physiol Opt. 1986;6(1):81-4.
Dark adaptation was measured for patients with age-related maculopathy (ARM) and for age-matched controls; green and red test stimuli were flashed 15 degrees from the fovea to examine differential effects of ARM on rod and cone functions, respectively. The ARM patients showed decreases in sensitivity for both rods and cones (0.5-1.5 log units) and an increased time constant of recovery for rod function. After 20 min in the dark, sensitivity to both red and green stimuli was depressed at the fovea and at 5, 10, 15 and 25 degrees eccentric to the fovea. The greatest sensitivity loss was found in the macular area (fovea and 5 degrees eccentric). Our data suggest that the ARM patients have an abnormality in both rod- and cone-adaptation systems over a relatively large retinal area which extends beyond the zone of visual field abnormality.
对年龄相关性黄斑病变（ARM）患者和年龄匹配的对照组进行了暗适应测量；绿色和红色测试刺激物在中央凹15度处闪烁，分别检查ARM对视杆和视锥功能的不同影响。ARM患者的视杆和视锥敏感度均下降（0.5 - 1.5对数单位），视杆功能的恢复时间常数增加。在黑暗中20分钟后，中央凹以及中央凹偏心5、10、15和25度处对红色和绿色刺激的敏感度均降低。黄斑区域（中央凹和偏心5度）的敏感度损失最大。我们的数据表明，ARM患者在相对较大的视网膜区域内，视杆和视锥适应系统均存在异常，该区域超出了视野异常区域。
