Sexton M, Nowicki P, Hebel J R
Prev Med. 1986 Jan;15(1):28-34. doi: 10.1016/0091-7435(86)90033-2.
A simple method of obtaining an unbiased verification of smoking status was developed for use in a randomized clinical trial. At the end of smoking cessation intervention for pregnant women, each participant mailed a saliva sample to a laboratory for the determination of thiocyanate. For comparison, salivary thiocyanate also was measured by a standard collection method in a reference group of non-study women who did not smoke during pregnancy. Although there may have been up to a 1-week delay between collection and analysis, results show that thiocyanate from unrefrigerated, mailed samples of saliva distinguishes reported smokers from nonsmokers, is positively associated with the amount of smoking, and is negatively associated with the length of cessation. These study findings are consistent with results from other studies in which samples of serum or saliva were collected and shipped under conditions requiring the presence of a staff member. The ability to perform an unbiased smoking status verification using a simple, inexpensive, and noninvasive collection method expands study possibilities, as it eliminates the need for direct, face-to-face contact with study subjects, and for being at their location.
一种用于随机临床试验的获得吸烟状况无偏倚验证的简单方法被开发出来。在孕妇戒烟干预结束时，每位参与者将一份唾液样本邮寄到实验室以测定硫氰酸盐。作为对照，还通过标准采集方法在孕期不吸烟的非研究女性参考组中测量了唾液硫氰酸盐。尽管采集和分析之间可能有长达1周的延迟，但结果表明，来自未冷藏、邮寄的唾液样本中的硫氰酸盐能够区分报告的吸烟者和非吸烟者，与吸烟量呈正相关，与戒烟时长呈负相关。这些研究结果与其他研究结果一致，在其他研究中，血清或唾液样本是在需要工作人员在场的条件下采集和运送的。使用简单、廉价且非侵入性的采集方法进行无偏倚吸烟状况验证的能力扩展了研究可能性，因为它消除了与研究对象直接面对面接触以及前往他们所在地点的需求。
