Paré W P
Am J Dig Dis. 1975 Mar;20(3):262-73. doi: 10.1007/BF01070729.
Rats housed in activity cages and fed 1 hour daily died before the end of the 21-day experimental period and revealed extensive ulcers in the glandular stomach, whereas food-yoked control rats, not housed in activity cages, did not die and were ulcer-free. Rats demonstrating high running-activity levels under ad lib feeding conditions subsequently revealed a higher incidence of lesions as compared to low-activity rats. Attempts to attenuate activity and lesion incidence by reversing the light-dark cycle failed, but the higher mortality level in rats under the reversed light-dark condition was related to higher activity levels in these rats. Young rats with high activity levels died sooner and had ulcers when compared to older rats with low activity levels. These results suggested that running activity, and not reduced food intake, was critically involved in the development of the activity-stress ulcer.
饲养在活动笼中且每天仅喂食1小时的大鼠在21天实验期结束前死亡，腺胃出现广泛溃疡，而未饲养在活动笼中的食物配对对照大鼠未死亡且无溃疡。在自由采食条件下表现出高跑步活动水平的大鼠，与低活动水平的大鼠相比，随后出现病变的发生率更高。通过颠倒明暗周期来减弱活动和病变发生率的尝试失败了，但在颠倒明暗条件下大鼠的较高死亡率与这些大鼠较高的活动水平有关。与低活动水平的老年大鼠相比，高活动水平的幼鼠死亡更早且有溃疡。这些结果表明，跑步活动而非食物摄入量减少，与活动应激性溃疡的发生密切相关。
