Department of Epidemiology and Public Health, Federal Rural University of Rio de Janeiro, Seropédica, RJ, Brazil.
Department of Veterinary Medicine, Federal University of Viçosa, Viçosa, MG, Brazil.
Appl Microbiol Biotechnol. 2023 Jun;107(12):3859-3868. doi: 10.1007/s00253-023-12525-0. Epub 2023 May 6.
The control of gastrointestinal parasites in animals has become more challenging every year due to parasite resistance to conventional chemical control, which has been observed worldwide. Ovicidal or opportunistic fungi do not form traps to capture larvae. Their mechanism of action is based on a mechanical/enzymatic process, which enables the penetration of their hyphae into helminth eggs, with subsequent internal colonization of these. The biological control with the Pochonia chlamydosporia fungus has been very promising in the treatment of environments and prevention. When used in intermediate hosts of Schistosoma mansoni, the fungus promoted a high percentage decrease in the population density of aquatic snails. Secondary metabolites were also found in P. chlamydosporia. Many of these compounds can be used by the chemical industry in the direction of a commercial product. This review aims to provide a description of P. chlamydosporia and its possible use as a biological parasitic controller. The ovicidal fungus P. chlamydosporia is effective in the control of parasites and goes far beyond the control of verminosis, intermediate hosts, and coccidia. It can also be used not only as biological controllers in natura but also as their metabolites and molecules can have chemical action against these organisms. KEY POINTS: • The use of the fungus P. chlamydosporia is promising in the control of helminths. • Metabolites and molecules of P. chlamydosporia may have chemical action in control.
由于寄生虫对常规化学控制的抗药性，动物的胃肠道寄生虫控制每年都变得更加具有挑战性，这种情况在全球范围内都有观察到。杀卵或机会性真菌不会形成陷阱来捕获幼虫。它们的作用机制基于机械/酶过程，使它们的菌丝穿透蠕虫卵，并随后在这些卵内进行内部定植。使用波氏多毛孢菌真菌对环境和预防进行生物控制非常有前途。当在曼氏血吸虫的中间宿主中使用时，该真菌促进了水生蜗牛种群密度的高百分比下降。在波氏多毛孢菌中也发现了次生代谢物。这些化合物中的许多可被化学工业用于开发商业产品。本综述旨在描述波氏多毛孢菌及其作为生物寄生虫控制器的可能用途。杀卵真菌波氏多毛孢菌在控制寄生虫方面非常有效，其效果远不止控制寄生虫病、中间宿主和球虫病。它不仅可以在自然环境中用作生物控制器，其代谢物和分子也可以对这些生物产生化学作用。要点：
• 真菌波氏多毛孢菌在控制蠕虫方面有很大的应用前景。
• 波氏多毛孢菌的代谢物和分子可能具有控制作用的化学活性。
